Tri-Institutional Training Program in Vision Research

描述(由申请人提供)：威尔·康奈尔医学院(WCMC)、斯隆-凯特琳研究所(SKI)和洛克菲勒大学(RU)这三所相邻机构的教职员工申请资金，以继续14年前开始的视觉研究合作三机构培训计划(TTPVR)。目前的TTPVR包括一套针对博士生和博士后研究员的综合培训活动。这些学院的优势和多样性为研究视网膜细胞和发育生物学、遗传学、神经再生、发育和可塑性、免疫学、结构生物学、信号转导和眼睛和大脑水平的信息处理提供了机会。各种研究项目利用了大量的方法，如分子和细胞生物学、酵母和小鼠遗传学、基因转移和基因治疗、结晶学和其他结构方法、电生理学、成像、高分辨率光学显微镜、行为学、计算机建模和流行病学。视力培训资源的汇集导致了项目的丰富，而不是个别机构提供的项目，促进了 参与的基础科学教员之间以及与临床教员之间的合作，为聘用新的视觉学院或吸引现有教师进入视觉研究提供了独特的机会。项目教师和学生之间的互动通过Vision研讨会系列，每周Vision期刊俱乐部，临床学术人员设计的课程，让基础视力科学家接触临床上看到的视力障碍，各种其他涉及视力研究不同方面的课程，纽约视力研究俱乐部每年3次的会议，有NIH资助的三个城市Vision培训计划的成员参加，以及Arvo后的年度海报会议。这种强烈的接触为更敏锐地了解临床问题和选择研究领域提供了一种工具，这些研究领域将临床和基础科学家联合起来，寻求治愈致盲疾病。请求NIH支持拟议的视觉研究三机构培训计划是基于三个参与机构的主要承诺，即教师、资金和致力于视觉研究的研究空间。

DESCRIPTION (provided by applicant): Faculty of three contiguous institutions, Weill Cornell Medical College (WCMC), Sloan-Kettering Institute (SKI), and The Rockefeller University (RU), request funds to continue a collaborative tri-institutional training program in vision research (TTPVR) started fourteen years ago. The current TTPVR consists of an integrated set of training activities for PhD students and postdoctoral fellows. The strengths and diversities of the faculties provide opportunities for research in retinal cell and developmental biology, genetics, neural regeneration, development and plasticity, immunology, structural biology, signal transduction, and information processing at the level of the eye and the brain. The various research projects utilize a vast array of methodologies, such as molecular and cell biology, yeast and mouse genetics, gene transfer and gene therapy, crystallography and other structural approaches, electrophysiology, imaging, high resolution optical microscopy, behavior, computer modeling, and epidemiology. The pooling of resources for vision training leads to an enrichment of programs over and above those available at the individual institutions, promotes collaborations between participating basic science faculty, as well as with clinical faculty, and provides a unique opportunity for the hiring of new Vision Faculty or attracting existing faculty into Vision Research. Interaction between Program Faculty and students takes place via a Vision seminar series, a weekly Vision journal club, a course by clinical-academic faculty designed to expose basic vision scientists to vision disorders seen in the clinic, various other courses dealing with different aspects of vision research, 3 times per year meetings of the New York Vision Research Club attended by members of three NIH-funded Vision Training Programs in the city and an annual post-ARVO poster session. This intense exposure provides a vehicle for a keener understanding of clinical problems and for the selection of research areas that unite clinical and basic scientists in the quest to cure blinding diseases. The request for NIH support of a proposed Tri-lnstitutional Training Program in Vision Research builds on major commitments by the three participating institutions of faculty, funds and research space devoted to vision research.