Core Grant for Vision Research

视觉研究核心资助

• 批准号: 10005437
• 负责人: W MATTHEW PETROLL
• 金额: $ 64.8万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005437
• 关键词: Adenoviruses; Area; Award; Basic Science; Biometry; Cell Culture Techniques; Cell Line; Cells; Center Core Grants; Collaborations; Complex; Contract Services; Core Facility; Core Grant; DNA; Data Analyses; Development; Environment; Equipment; Experimental Designs; Faculty; Foundations; Funding; Goals; Institution; Maintenance; Medical Students; Medical center; Molecular Biology; Ophthalmology; Outcome; Phenotype; Postdoctoral Fellow; Privatization; Production; Productivity; Publications; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Scientist; Services; Structure; Subfamily lentivirinae; Techniques; Time; Tissues; Training; Universities; Validation; Virus; Vision; Vision research; Work; cellular imaging; cost effective; design; digital imaging; equipment training; experience; experimental analysis; graduate student; improved; member; microscopic imaging; novel; operation; programs; quantitative imaging; ranpirnase; recruit; research study; vision development; vision science

Abstract: The overall goal of this NEI Core Center Grant for Vision Research is to enhance the capabilities of vision research scientists by facilitating easy access to equipment, training and technical support which will expand experimental capabilities, result in more cost-effective and time-efficient research, and open up new research directions. This Center will serve vision science researchers across the UT Southwestern Medical Center (UTSW) campus. It will also facilitate new research collaborations and utilization of the core facilities by vision scientists at other nearby institutions. Our proposed NEI Core Center consists of three Resource/Service Modules, each directed by a faculty member with experience and expertise in their unit’s focus area: 1) Cell Culture and Cell Phenotyping (Directed by Dr. Danielle Robertson), which will support the maintenance and authentication of cell lines that are required for rigorous study across a wide range of research activities, and provide equipment and support for quantitative cellular analysis applications; 2) Molecular Biology/Virus Production (Directed by Dr. John Hulleman), which will provide full service DNA production and validation as well as lentivirus and adenovirus production and purification; and, 3) Microscopy and Digital Imaging (Directed by Dr. Matthew Petroll), which will provide equipment, infra-structural support, supplies and technical assistance for quantitative imaging of cells and tissues. In addition, the Center includes a biostatistician who will work with Investigators on the design of their research studies, rigorous analysis of their data, and interpretation of their results. The Specific Aims of the Core Center are to enhance, streamline and add scientific rigor to the research activities of the participating vision scientists by: 1) Supporting the operation of the Resource/Service Modules by managing usage and operations, and providing for skilled technical assistance, equipment maintenance, and the purchase of supplies; 2) providing biostatistical services to Core investigators for the design and analysis of their research studies; 3) expanding the number of collaborative research projects between investigators both within UTSW and between UTSW and other neighboring institutions; 4) creating a more fertile environment for the development of vision research programs of junior faculty members, and for new vision researchers recruited into the University; and, 5) providing resources and training to assist graduate students, medical students, and post-doctoral fellows with their research. Overall, we anticipate that the Core Grant for Vision Research will impact the research programs of these researchers by allowing them to: 1) expand into new research areas through the addition of novel experimental techniques; 2) develop new collaborations with other Core Center users throughout the region; 3) improve their productivity and efficiency through the use of Core services; and, 4) optimize their experimental design and analysis to maintain a high level of rigor and reproducibility.

摘要： 这个NEI视觉研究核心中心拨款的总体目标是提高视觉的能力， 研究科学家通过方便获得设备，培训和技术支持，这将扩大 实验能力，导致更具成本效益和时间效率的研究，并开辟新的研究 方向该中心将为UT西南医学中心的视觉科学研究人员提供服务 （UTSW）campus.此外，中心亦会促进新的研究合作，以及促进视觉中心使用核心设施 附近其他机构的科学家。 我们建议的NEI核心中心由三个资源/服务模块组成，每个模块由一名教师指导 在其单位的重点领域具有经验和专业知识的成员：1）细胞培养和细胞表型分析（指导 Danielle Robertson博士），这将支持细胞系的维护和认证， 在广泛的研究活动中进行严格的研究所需的，并提供设备和支持， 定量细胞分析应用; 2）分子生物学/病毒生产（由John博士指导 Hulleman），该公司将提供全方位的DNA生产和验证服务，以及慢病毒和腺病毒 生产和纯化;以及3）显微镜和数字成像（由Matthew Petroll博士指导）， 将提供设备、基础设施支持、用品和技术援助， 细胞和组织。此外，该中心还包括一名生物统计学家，他将与研究者合作， 他们的研究设计，他们的数据的严格分析，并解释他们的结果。 核心中心的具体目标是加强，精简和增加科学严谨的研究 1）支持资源/服务模块的运行 通过管理使用和操作，并提供熟练的技术援助，设备维护， 和购买用品; 2）为核心研究者提供生物统计服务， 分析他们的研究; 3）扩大合作研究项目的数量， UTSW内部以及UTSW与其他邻近机构之间的调查人员; 4）创建一个更 肥沃的环境，为初级教师的视觉研究计划的发展，并为新的 视觉研究人员招募到大学;和，5）提供资源和培训，以帮助毕业生 学生，医学生和博士后研究员进行研究。 总的来说，我们预计视觉研究的核心补助金将影响这些研究项目。 研究人员通过允许他们：1）通过增加新的实验扩展到新的研究领域 技术; 2）与整个地区的其他核心中心用户开展新的合作; 3）提高他们的 通过使用核心服务提高生产力和效率;以及，4）优化实验设计， 分析，以保持高水平的严谨性和再现性。