Core Grant for Vision Research

视觉研究核心资助

• 批准号: 10438806
• 负责人: W MATTHEW PETROLL
• 金额: $ 64.8万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438806
• 关键词: Adenoviruses; Area; Award; Basic Science; Biometry; Cell Culture Techniques; Cell Line; Cells; Center Core Grants; Collaborations; Complex; Contract Services; Core Facility; Core Grant; DNA; Data Analyses; Development; Environment; Equipment; Experimental Designs; Faculty; Foundations; Funding; Goals; Institution; Lentivirus; Maintenance; Medical Students; Medical center; Molecular Biology; Ophthalmology; Outcome; Phenotype; Postdoctoral Fellow; Privatization; Production; Productivity; Publications; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Scientist; Services; Techniques; Time; Tissues; Training; Universities; Validation; Virus; Vision; Vision research; Work; cellular imaging; cost effective; design; digital imaging; equipment training; experience; experimental analysis; graduate student; improved; member; microscopic imaging; novel; operation; programs; quantitative imaging; ranpirnase; recruit; research study; vision development; vision science

Abstract: The overall goal of this NEI Core Center Grant for Vision Research is to enhance the capabilities of vision research scientists by facilitating easy access to equipment, training and technical support which will expand experimental capabilities, result in more cost-effective and time-efficient research, and open up new research directions. This Center will serve vision science researchers across the UT Southwestern Medical Center (UTSW) campus. It will also facilitate new research collaborations and utilization of the core facilities by vision scientists at other nearby institutions. Our proposed NEI Core Center consists of three Resource/Service Modules, each directed by a faculty member with experience and expertise in their unit’s focus area: 1) Cell Culture and Cell Phenotyping (Directed by Dr. Danielle Robertson), which will support the maintenance and authentication of cell lines that are required for rigorous study across a wide range of research activities, and provide equipment and support for quantitative cellular analysis applications; 2) Molecular Biology/Virus Production (Directed by Dr. John Hulleman), which will provide full service DNA production and validation as well as lentivirus and adenovirus production and purification; and, 3) Microscopy and Digital Imaging (Directed by Dr. Matthew Petroll), which will provide equipment, infra-structural support, supplies and technical assistance for quantitative imaging of cells and tissues. In addition, the Center includes a biostatistician who will work with Investigators on the design of their research studies, rigorous analysis of their data, and interpretation of their results. The Specific Aims of the Core Center are to enhance, streamline and add scientific rigor to the research activities of the participating vision scientists by: 1) Supporting the operation of the Resource/Service Modules by managing usage and operations, and providing for skilled technical assistance, equipment maintenance, and the purchase of supplies; 2) providing biostatistical services to Core investigators for the design and analysis of their research studies; 3) expanding the number of collaborative research projects between investigators both within UTSW and between UTSW and other neighboring institutions; 4) creating a more fertile environment for the development of vision research programs of junior faculty members, and for new vision researchers recruited into the University; and, 5) providing resources and training to assist graduate students, medical students, and post-doctoral fellows with their research. Overall, we anticipate that the Core Grant for Vision Research will impact the research programs of these researchers by allowing them to: 1) expand into new research areas through the addition of novel experimental techniques; 2) develop new collaborations with other Core Center users throughout the region; 3) improve their productivity and efficiency through the use of Core services; and, 4) optimize their experimental design and analysis to maintain a high level of rigor and reproducibility.

抽象的： NEI 核心中心视觉研究补助金的总体目标是增强视觉能力 研究科学家通过促进设备、培训和技术支持的便捷获取，这将扩大 实验能力，产生更具成本效益和时间效率的研究，并开辟新的研究 方向。该中心将为 UT 西南医学中心的视觉科学研究人员提供服务 （UTSW）校园。它还将通过愿景促进新的研究合作和核心设施的利用 附近其他机构的科学家。 我们提议的 NEI 核心中心由三个资源/服务模块组成，每个模块均由一名教员指导 在其单位重点领域具有经验和专业知识的成员：1) 细胞培养和细胞表型分析（定向 由 Danielle Robertson 博士撰写），这将支持细胞系的维护和认证 需要进行广泛的研究活动的严格研究，并提供设备和支持 定量细胞分析应用； 2) 分子生物学/病毒生产（由约翰博士指导） Hulleman），将提供 DNA 生产和验证以及慢病毒和腺病毒的全方位服务 生产和纯化； 3) 显微镜和数字成像（由 Matthew Petroll 博士指导），其中 将为定量成像提供设备、基础设施支持、用品和技术援助 细胞和组织。此外，该中心还包括一名生物统计学家，他将与研究人员合作 设计他们的研究，严格分析他们的数据，并解释他们的结果。 核心中心的具体目标是加强、简化研究并增加研究的科学严谨性 参与视觉科学家的活动： 1) 支持资源/服务模块的运行 通过管理使用和操作，并提供熟练的技术援助、设备维护， 以及物资的采购； 2）为核心研究人员提供生物统计服务，以进行设计和 分析他们的研究； 3）扩大合作研究项目的数量 UTSW 内部以及 UTSW 与其他邻近机构之间的调查员； 4）创建更多 为初级教员的视觉研究项目的发展和新的人员提供肥沃的环境 大学招募视觉研究人员； 5）提供资源和培训来帮助毕业生 学生、医学生和博士后研究员的研究。 总体而言，我们预计视觉研究核心拨款将影响这些机构的研究项目 研究人员可以：1）通过添加新的实验扩展到新的研究领域 技术； 2) 与整个地区的其他核心中心用户开展新的合作； 3）提高他们的 通过使用核心服务实现生产力和效率； 4) 优化他们的实验设计和 分析以保持高水平的严谨性和可重复性。