Vanderbilt Mouse Metabolic Phenotyping Center

描述(由申请人提供)：Vanderbilt小鼠代谢表型中心(VMMPC)成立于2001年，旨在通过为科学界提供标准化、高质量的糖尿病、糖尿病并发症和肥胖症小鼠模型的表型鉴定服务，促进医学和生物学研究。VMMPC由五个核心组成。行政核心提供科学、财务和行政领导。该核心还监督服务请求、数据管理，并跟踪在VMMPC研究的MICE。管理核心还负责VMMPC教育计划。动物健康和福利核心对提交给VMMPC的老鼠进行评估，监督群体的健康和福利，并确保遵守监管机构和MMPC指南。由代谢病理生理学核心(MPC)提供的服务强调研究清醒、无应激小鼠的能量平衡、胰岛素作用、激素分泌和新陈代谢的方法学。MPC还具有单独评估器官或胰岛功能的能力，并可以应用最先进的成像技术。心血管病理生理学和并发症核心有一系列测试来研究心血管疾病和其他糖尿病并发症。分析资源核心接收从VMMPC测试和在VMMPC之外进行的实验生成的样本。此核心执行的分析是特定于鼠标的，并可进行缩放以适应较小的样本量。VMMPC的存在是因为NIDDK的领导层的洞察力，VUMC对空间和资源的慷慨承诺，以及精心设计的基础设施。但VMMPC运作良好的主要原因是组成它的人。NIDDK在小鼠表型鉴定方面的实验需要一支愿意将作为他们研究生命线一部分的技术提供给科学界的教师，他们只需收回成本，并知道他们正在为更大的利益而工作。它需要一支技术娴熟、尽职尽责的工作人员，以至于科学家们愿意将他们的老鼠、他们的研究生命线委托给他们。

DESCRIPTION (provided by applicant): The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership. This Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Administrative Core is also responsible for the VMMPC educational program. The Animal Health and Welfare Core evaluates mice submitted to the VMMPC, oversees the health and welfare of the colony, and ensures compliance with regulatory bodies and MMPC guidelines. Services provided by the Metabolic Pathophysiology Core (MPC) emphasize methodology to study energy balance, insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MPC also has the capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The Cardiovascular Pathophysiology and Complications Core has a range of tests to study cardiovascular disease and other complications of diabetes. The Analytical Resources Core receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by this core are specific to the mouse and are scaled to accommodate small sample volumes. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from VUMC, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is the people that comprise it. This NIDDK experiment in mouse phenotyping requires a faculty that is willing to make technology that is part of their research lifeline available to the scientific community for no more than the recovery of costs and the knowledge that they are working for a greater good. It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them.