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Sphingolipid Biology of Inflammation and Immunity

Sphingolipid Biology of Inflammation and Immunity
炎症和免疫的鞘脂生物学
批准号：
8148855
负责人：
Richard Proia
金额：
$34.56万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8148855
关键词：
BiologyImmunityInflammationSphingolipids

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中文摘要
翻译
我们正在研究鞘脂调节免疫和炎症的机制。 我们的重点是鞘氨醇-1-磷酸（S1 P），一种富含血管和淋巴系统的生物活性脂质，以及在免疫细胞和内皮上发现的S1 P受体。 已经发现S1 P及其受体对于免疫系统发育和稳态以及对于免疫应答和炎症的调节的重要作用。 我们正在研究S1 P受体和鞘脂代谢途径在炎症和免疫中的作用。
英文摘要
We are studying the mechanism by which sphingolipids regulate immunity and inflammation. Our focus has been on sphingosine-1-phosphate (S1P), a bioactive lipid enriched in the vascular and lymphatic systems, and the S1P receptors, found on immune cells and the endothelium. Essential roles for S1P and its receptors have been found for immune system development and homeostasis as well as for the regulation of immune responses and inflammation. We are studying the individual roles of the S1P receptors and the sphingolipid metabolic pathway in inflammation and immunity.
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Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Neurodegeneration
Sphingolipid Biology and Regulation of Metabolism
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