Genetic insights into atherosclerosis and other cardiovascular diseases

通过我们之前使用人类血液和动脉粥样硬化斑块组织样本的基因组研究，我们确定了动脉粥样硬化疾病严重程度的标志物和他汀类药物治疗的胆固醇非依赖性标志物，已获得使用专利。 我们还鉴定了tristetraprolin锌指蛋白36（TTP）作为炎症性关节炎和动脉粥样硬化的重要的局部组织炎症的介质。随着我们目前对氧化应激和代谢的兴趣，这可能会影响炎症和动脉粥样硬化，我们正在进行研究，以检查它们对免疫系统的影响，使用体内模型。 例如，我们感兴趣的是研究氧稳态可能影响心血管疾病过程（如动脉粥样硬化）的机制。

Through our previous genomic studies using human blood and atherosclerotic plaque tissue samples, we identified a marker of atherosclerosis disease severity and a cholesterol-independent marker of statin treatment, which has been granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. With our current interest in oxidative stress and metabolism, which can affect inflammation and atherosclerosis, we are pursuing studies to examine their effect on the immune system using in vivo models. For example, we are interested in examining the mechanisms by which oxygen homeostasis may affect cardiovascular disease processes such as atherosclerosis.