CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource

CNS HIV抗逆转录病毒治疗效果研究（CHARTER）于2002年9月获得资助，以响应RFA NIMH-00-AI-0005，目的是探索在高效抗逆转录病毒治疗（HAART）背景下HIV神经系统并发症的变化。宪章的主要目的是确定如何中枢和外周神经系统并发症的艾滋病毒正在受到影响的不同的历史和方案的艺术。在过去的8年中，六个网站CHARTER项目已积累了宝贵的临床和研究数据的1598名参与者，纵向数据收集这些参与者中的674。数据包括神经医学表征，神经心理功能，精神和药物滥用变量，治疗数据，脑成像，病毒和宿主遗传学信息。每次访问CHARTER都会产生大约4000个独立变量;目前数据库包含超过500万个数据点。 CHARTER的一个关键组成部分是通过向调查人员提供这一丰富的数据，作为进一步研究/分析的催化剂。迄今为止，CHARTER协调核心和CHARTER资源已经为18个机构的70名研究人员的研究请求提供了便利。 为了继续向neuroAIDS社区提供样本和数据，我们建议将“宪章作为资源”设施延长到最初的宪章选择期之后。

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in September 2002 in response to RFA NIMH-00-AI-0005 with the aim of exploring the changing presentation of HIV neurological complications in the context of highly active antiretroviral therapy (HAART). CHARTER¿s major aims were to determine how central and peripheral nervous system complications of HIV were being affected by different histories and regimens of ART. Over the past 8 years, the six-site CHARTER project has accumulated invaluable clinical and research data on 1598 participants, with longitudinal data being collected on 674 of these participants. Data includes neuromedical characterization, neuropsychological functioning, psychiatric and drug abuse variables, treatment data, brain imaging, and viral and host genetics information. Each CHARTER visit generates approximately 4000 individual variables; currently the database contains over 5 million datapoints. A key component of CHARTER is to serve as a catalyst for additional studies/analyses by making this wealth of data available to investigators. To date, the CHARTER Coordinating Core and CHARTER Resource have facilitated research requests for 70 investigators across 18 institutions. In order to continue to make samples and data available to the neuroAIDS community, we propose to extend the ¿CHARTER as a Resource¿ facilities beyond the original CHARTER Option Period.