Alzheimer Disease Research Center

描述（由申请人提供）：南加州大学（USC）的阿尔茨海默病研究中心（ADRC）专注于减少阿尔茨海默病和血管对不同人群认知障碍的贡献。ADRC将大脑健康放在衰老的神经生物学和心理学的大背景下，认为阿尔茨海默病（AD）和脑血管病（CVD）是病理性认知能力下降的两个主要原因。我们已经建立了一个跨学科的团队，在基础科学和临床试验之间建立桥梁，早在术语“转化”研究流行之前。本次更新申请包括三个加强转化研究的项目。我们的人群包括一项针对长滩纵向研究（LBLS）中的白种人的15年前瞻性研究，一项针对洛杉矶拉丁裔眼科研究（LALES）中的西班牙裔的10年前瞻性研究，以及一项新资助的基于社区的华裔美国人眼科研究（CHES）。几个附属队列包括衰老脑计划项目（PLChui）和黄体酮与脑衰老和阿尔茨海默病（PI: R. Brinton）。

DESCRIPTION (provided by applicant): The Alzheimer Disease Research Center (ADRC) at the University of Southern California (USC) focuses on Reducing Alzheimer and Vascular Contributions to Cognitive Impairment in Diverse Populations. The ADRC views brain health in the broad context of the neurobiology and psychology of aging, with Alzheimer Disease (AD) and cerebrovascular disease (CVD) as the two major causes of pathological cognitive decline. We have built an interdisciplinary team to bridge basic science to clinical trials, well before the term "translational" research became popular. This renewal application includes three projects which strengthen translational research. Our populations include a 15-year prospective study of Caucasians enrolled in the Long Beach Longitudinal Study (LBLS), a 10-year prospective study of Hispanics in the community-based Los Angeles Latino Eye Study (LALES) and a newly funded, community-based Chinese American Eye Study (CHES). Several affiliated cohorts include the Aging Brain Program Project (PLChui) and the Progesterone and Brain Aging and Alzheimer Disease (PI: R. Brinton). During the next five years, we will focus on the following overarching goals: 1) Clarify the pathological and phenotypic interactions between AD and CVD, 2) Increase recruitment and retention of minority subjects from LALES, CHES, and the surrounding neighborhood, 3) Promote clinical trials and translational research in memory and aging at USC, and 4) Continue active participation in national initiatives, including National Alzheimer Coordinating Center (NACC), Alzheimer Disease Cooperative Study (ADCS), Alzheimer Disease Neuroimaging Initiative (ADNI), and Genome Wide Association Study (GWAS). The ADRC comprise 6 Cores (Administration, Data, Clinical, Education, Pathology, and Imaging) and 3 Projects: Zelinski (Course of Cognitive Change in Late Adulthood), Brinton/Pike (Novel NeuroSERMs and NeuroSARMs for protection against Alzheimer pathology), and Zheng (Cognitive Impairment in a Chinese American Community).