Incidence, Latency, and Survival of Cancer Following World Trade Center Exposure

摘要： 2001年9月11日(9月11日)对世界贸易中心(WTC)的袭击涉及两起 飞机撞向建筑物，燃烧了数千磅的喷气燃料。这个 随后的塔楼坍塌，以及随后的救援/恢复工作，导致了 暴露在各种危险物质中的应急者人数，包括 粉状水泥、玻璃、石棉、铅、多环芳烃(PAHs)、 多氯联苯、有机氯农药和多氯呋喃 二恶英(1-3)。跟踪救援和恢复工作人员队列的三个研究中心 WTC的灾难包括纽约市消防局(FDNY)；伊坎学校 西奈山医学部(ISMMS)和纽约市卫生与心理部门 卫生(DOHMH)。癌症发病率虽然不是很高，但大多没有统计上的显着升高 所有三个队列中都报告了接触WTC-Site后的情况，尽管有限 2001年9月11日以来的随访时间(4-7)。我们建议将这三个群体结合起来，以说明 在多个队列中的个人，以增加样本大小，并使 结果具有更强的通用性。我们计划从以前的报告中更新发病情况 使用一致的暴露和结果定义，并利用另外六个 自这些出版物发表以来，已有多年的后续行动。我们还计划研究从世贸中心到- 暴露于与WTC相关的癌症发病率增加。我们认为，这一短期内 在应答者队列中进行高强度暴露和长期随访，结合这些 分析，为研究人类癌症潜伏期提供了难得的机会。最后，我们还 建议对WTC癌症救援/康复人员的癌症存活率进行首个研究。

Abstract: The attacks on the World Trade Center (WTC) on 9/11/2001 (9/11) involved collision of two aircraft into the buildings and the combustion of many thousands of pounds of jet fuel. The subsequent collapse on the towers, and the rescue/recovery effort that followed, led to large numbers of responders being exposed to a wide variety of hazardous material including pulverized cement, glass, asbestos, lead, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), organochlorine pesticides, and polychlorinated furans and dioxins (1-3). Three research centers that follow cohorts of rescue and recovery workers since the WTC disaster include the Fire Department of the City of New York (FDNY); the Icahn School of Medicine at Mount Sinai (ISMMS); and the New York City Department of Health and Mental Hygiene (DOHMH). Modest though mostly non-statistically significantly elevated cancer rates post-exposure to the WTC-site have been reported in all three of the cohorts, despite limited follow-up time since 9/11/2001 (4-7). We propose to combine these three cohorts to account for individuals who are in more than one cohort, to increase the sample size, and to make the results more generalizable. We plan to update the incidence findings from the prior reports using consistent exposure and outcome definitions and taking advantage of the additional six years of follow-up since those publications. We also plan to study the time elapsed from WTC- exposure to increased incidence of WTC-associated cancer. We believe that this short-term high intensity exposure with long-term follow-up in responder cohorts, combined for these analyses, offers a rare opportunity to investigate cancer latency in humans. Finally, we also propose the first study of cancer survival in WTC rescue/recovery workers with cancer.