PET imaging agents for the differential diagnosis of hypoxic tumors

从不断增加的化疗药物库中选择最好的治疗方法是至关重要的。肿瘤缺氧需要专科治疗和患者选择。目前的PET显像剂不能区分严重和轻度缺氧肿瘤。我们已经发现了一种可以检测轻度缺氧肿瘤的新试剂，这项拨款申请的目的是进一步开发这种放射性示踪剂，以提高图像质量和诊断的可靠性。

Choosing the best type of treatment from the ever increasing arsenal of chemotherapeutic agents against cancer is of critical importance. Tumor hypoxia requires specialized treatment and patient selection. Current PET imaging agents cannot differentiate between severely and mildly hypoxic tumors. We have found a new agent that can detect mildly hypoxic tumors and the aim of this grant application is to further develop this radiotracer to improve image quality and reliability of the diagnosis.