Asymmetric cell divison in T cell development: consequences for immunity and cancer

人类健康取决于免疫系统的发展，该系统可以有效地控制感染而不损害正常组织。在这个项目中，我们评估了一种新的范式，通过这种范式可以控制免疫细胞的发育，其中免疫细胞前体以这样一种方式分裂，即它的两个女儿继承不同的分子组成，随后调节不同细胞命运的通过。这种现象对免疫和癌症的可能后果将被探讨。

Human health depends upon the development of an immune system that can effectively control infection without damaging normal tissue. In this project, we assess a new paradigm by which immune cell development might be controlled, in which an immune cell precursor divides in such a way that its two daughters inherit different molecular constitutents that subsequently regulate the adoption of different cell fate. The likely consequences of this phenomonon on immunity and cancer will be explored.