CNS peptides involved in the control of thermogenesis and body weight

目前，肥胖症在所有工业化国家都有流行，这对心血管疾病和相关的疾病，如2型糖尿病有相关的影响。目前的治疗战略侧重于减少食物摄入量，但正如这一流行病的持续所证明的那样，这些战略收效甚微。另一种办法是确定和修改控制能源支出的中央调解人，这也是本项目的主题。我们将带来大量新技术来研究这个问题，并可能确定治疗肥胖症的新途径。

There is currently an obesity epidemic in all industrialised countries which has an associated impact on cardiovascular disease and associated pathologies such as type 2 diabetes. Current therapeutic strategies have focussed on reducing food intake but, as evidenced by the continuation of this epidemic, these have had limited success. An alternative approach, which is the subject of this project, is to determine and modify the central mediators controlling energy expenditure. We will bring a raft of new technologies to examine this question and potentially identify new avenues for therapeutic intervention in obesity.