Ionic-liquid-supported synthesis

本文提出了可溶离子液体可以作为催化剂/试剂固定和均相合成的载体。由于离子液体载体的范围很广，它们作为载体的使用可能与大多数常见的合成化学物质兼容。这些离子液体载体的溶解度可以通过阳离子和阴离子的变化来调节，使其与极性较小的有机溶剂和水介质相分离。因此，离子液体支持的物质可以通过简单的洗涤从反应混合物中纯化出来。离子液体负载的催化剂和试剂将被制备、使用和再利用。小分子的平行和组合文库已经被合成。离子液体负载合成（ILSS）将应用于多肽、寡糖和寡核苷酸的制备。在适用的情况下，将重点介绍ILSS与固相合成、可溶聚合物支撑合成和氟相合成的比较。

In this proposal, it is suggested that soluble ionic liquids can be used as supports for catalyst/reagent immobilization and synthesis in homogeneous solution phase.  Because of the wide range of ionic liquid supports available, their use as supports is likely to be compatible with most common synthetic chemistries.  The solubility properties of these ionic liquid supports can be tuned by the variation of cations and anions to make them phase separate from less polar organic solvents and aqueous media.  The ionic liquid-supported species can therefore be purified from the reaction mixture by simple washings.   Ionic liquid-supported catalysts and reagents will be prepared and used and reused.  Parallel and combinatorial libraries of small molecules have been synthesized.  Ionic liquid-supported synthesis (ILSS) will applied to the preparation of peptides, oligosaccharides and oligonucleotides.  The comparison of ILSS with solid-phase synthesis, soluble-polymer supported synthesis and fluorous phase synthesis will be highlighted where applicable.