Regulation of gastric tumour invasion and growth by gp130 activating cytokines.

胃癌是世界范围内发病率和死亡率的主要原因。我们以前已经建立了一种非常有信息量的这种疾病的动物模型，这有助于对IL-6家族细胞因子在调节胃肿瘤生长和向远处器官扩散中的不同作用有新的理解。本提案将重点阐述该细胞因子家族的主要成员，即IL-6和IL-11如何分别抑制肿瘤对其他器官的侵袭和促进肿瘤的生长。对这些过程的了解将有助于设计针对每种细胞因子的治疗干预措施，并可能导致旨在限制或逆转这种疾病的药物。

Gastric cancer is a major cause of morbidity and death worldwide. We have previously established a very informative animal model of this disease which has facilitated a new understanding of the diverse role of the IL-6 family of cytokines in regulating gastric tumour growth and dissemination to distant organs. This proposal will focus on how the main members of this cytokine family, namely IL-6 and IL-11, inhibit gastric tumour invasion to other organs, and promote tumour growth respectively . An understanding of these processes will aid in designing therapeutic interventions specific for each cytokine and which may lead to drugs aimed at limiting or reversing this disease.