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Regulation of haematopoietic stem cells through histone modifications

Regulation of haematopoietic stem cells through histone modifications
通过组蛋白修饰调节造血干细胞
批准号:
nhmrc : 1084248
负责人:
A/Pr Anne Voss
金额:
$53.14万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

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中文摘要
翻译
遗传物质用组蛋白包裹在细胞核中。组蛋白的修饰决定了基因组的某个特定区域是活跃的还是被抑制的。我们正在研究一个组蛋白修饰蛋白家族,MYST蛋白。这些蛋白质的突变会导致智力残疾和血癌。在这个项目中,我们研究MYST2在血液干细胞中的作用。所获得的知识可能成为开发治疗癌症的药物的基础。
英文摘要
The genetic material is packaged in the cell nucleus with histone proteins. Modifications of histones determine if a particular area of the genome is active or repressed. We are investigating a family of histone modifying proteins, the MYST proteins. Mutations in these proteins cause intellectual disability and blood cancer. In this project we examine the role of MYST2 in blood stem cells. Knowledge gained may become the basis for the development of drugs for the treatment of cancer.
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会议论文
The molecular and biological roles of growth inhibiting chromatin binding proteins
  • 批准号:
    nhmrc : GNT1143612
  • 项目类别:
    Project Grants
  • 资助金额:
    $81.48万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Anne Voss
  • 依托单位:
The molecular and biological roles of growth inhibiting chromatin binding proteins
Chromatin regulation of neural stem cell multipotency
TAF8 is a suppressor of cell death
海外基金