Regulation of haematopoietic stem cells through histone modifications
Regulation of haematopoietic stem cells through histone modifications
批准号:
nhmrc : 1084248
负责人:
A/Pr Anne Voss
金额:
$53.14万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
遗传物质用组蛋白包裹在细胞核中。组蛋白的修饰决定了基因组的某个特定区域是活跃的还是被抑制的。我们正在研究一个组蛋白修饰蛋白家族,MYST蛋白。这些蛋白质的突变会导致智力残疾和血癌。在这个项目中,我们研究MYST2在血液干细胞中的作用。所获得的知识可能成为开发治疗癌症的药物的基础。
英文摘要
The genetic material is packaged in the cell nucleus with histone proteins. Modifications of histones determine if a particular area of the genome is active or repressed. We are investigating a family of histone modifying proteins, the MYST proteins. Mutations in these proteins cause intellectual disability and blood cancer. In this project we examine the role of MYST2 in blood stem cells. Knowledge gained may become the basis for the development of drugs for the treatment of cancer.
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会议论文
The molecular and biological roles of growth inhibiting chromatin binding proteins
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批准号:nhmrc : GNT1143612
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项目类别:Project Grants
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资助金额:$81.48万
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财政年份:2018
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负责人:A/Pr Anne Voss
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依托单位:
The molecular and biological roles of growth inhibiting chromatin binding proteins
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批准号:nhmrc : 1143612
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项目类别:Project Grants
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资助金额:$55.09万
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财政年份:2018
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负责人:A/Pr Anne Voss
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依托单位:
Chromatin regulation of neural stem cell multipotency
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批准号:nhmrc : 1084352
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项目类别:Project Grants
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资助金额:$50.42万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
TAF8 is a suppressor of cell death
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批准号:nhmrc : 1084504
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项目类别:Project Grants
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资助金额:$38.04万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
NHMRC Research Fellowship
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批准号:nhmrc : GNT1081421
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项目类别:Research Fellowships
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资助金额:$61.16万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
MOZ regulates cellular senescence
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批准号:nhmrc : 1084509
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项目类别:Project Grants
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资助金额:$33.24万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
TAF8 is a suppressor of cell death
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批准号:nhmrc : GNT1084504
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项目类别:Project Grants
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资助金额:$55.26万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
NHMRC Research Fellowship
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批准号:nhmrc : 1081421
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项目类别:Research Fellowships
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资助金额:$42.58万
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财政年份:2015
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负责人:A/Pr Anne Voss
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依托单位:
Understanding the regulation of craniofacial development through control of chromatin and gene transcription
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批准号:nhmrc : 1051078
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项目类别:Project Grants
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资助金额:$41.1万
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财政年份:2013
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负责人:A/Pr Anne Voss
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依托单位:
The role of Moz, an epigenetic regulator, in the pathogenesis of leukaemia
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批准号:nhmrc : 1030704
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项目类别:Project Grants
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资助金额:$47.6万
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财政年份:2012
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负责人:A/Pr Anne Voss
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依托单位:
Understanding the control of brain development and endocrine function through central regulation of gene transcription
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批准号:nhmrc : 1029481
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项目类别:Project Grants
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资助金额:$41.66万
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财政年份:2012
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负责人:A/Pr Anne Voss
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依托单位:
Interaction between Moz and PRC1 in defining epigenetic states and gene expression patterns
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批准号:nhmrc : 1008699
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项目类别:Project Grants
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资助金额:$28.49万
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财政年份:2011
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负责人:A/Pr Anne Voss
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依托单位:
Effects of the histone acetyltransferases MOZ and QKF on chromatin modifications
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批准号:nhmrc : 1010851
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项目类别:Project Grants
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资助金额:$23.31万
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财政年份:2011
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负责人:A/Pr Anne Voss
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依托单位:
The role of the suppressors of cytokine signalling 6 and 7 in cerebral cortex development
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批准号:nhmrc : 637346
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项目类别:NHMRC Project Grants
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资助金额:$25.15万
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财政年份:2010
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负责人:A/Pr Anne Voss
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依托单位:
The role of the transcriptional co-activator, Qkf, in adult neural stem cell self-renewal and multi-potency.
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批准号:nhmrc : 575557
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项目类别:NHMRC Project Grants
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资助金额:$26.92万
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财政年份:2009
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负责人:A/Pr Anne Voss
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 575512
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项目类别:NHMRC Research Fellowships
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资助金额:$46.88万
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财政年份:2009
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负责人:A/Pr Anne Voss
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依托单位:
The role of the Ras signalling molecule, C3G, in the interaction of neural precursor cells and their environment
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批准号:nhmrc : 461215
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项目类别:NHMRC Project Grants
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资助金额:$21.3万
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财政年份:2007
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负责人:A/Pr Anne Voss
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依托单位:
Body segment identity specification by the transcription regulator, Moz
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批准号:nhmrc : 461216
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项目类别:NHMRC Project Grants
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资助金额:$24.43万
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财政年份:2007
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负责人:A/Pr Anne Voss
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依托单位:
The role of the MYST family transcriptional co-activator, Mof, in embryonic development
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批准号:nhmrc : 461218
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项目类别:NHMRC Project Grants
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资助金额:$21.3万
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财政年份:2007
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负责人:A/Pr Anne Voss
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依托单位:
The role of MOZ in the development of the hematopoietic system, spleen and thymus
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批准号:nhmrc : 356228
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项目类别:NHMRC Project Grants
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资助金额:$21.63万
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财政年份:2005
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负责人:A/Pr Anne Voss
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依托单位:
海外基金