New methods for synthetic organic chemistry

我的小组的主要研究目标是开发新的合成方法，重点是催化对映选择程序，以简单直接地制备生物学和商业上重要的分子。该项目的具体目标包括利用铋（III）盐开发催化反应。我们希望探索铋盐的催化作用，因为铋是一种廉价且无毒的元素。此外，路易斯酸能够在温和和环境友好的条件下催化对映选择性反应，这对合成化学家来说是一个非凡的挑战。该项目的创新元素是利用铋（III）盐开发催化对映选择性反应。文献中涉及催化不对称Mukaiyama醛醇反应的例子非常有限。在这种情况下，显然需要开发新的手性铋（III）催化剂，这种催化剂价格便宜，易于处理，并且具有足够的刘易斯酸。我们希望将基于铋（III）的对映选择程序的发展扩展到mannich型反应。本项目属于使用铋（III）催化剂进行不对称有机合成的研究领域。这个领域非常重要，因为它使加拿大在制药和精细化学工业中处于卓越水平。我们提出的研究计划将有助于在合成有机化学和药物化学领域培养高度专业化的人才。

The primary research objective in my group is the development of new synthetic methods, with emphasis oncatalytic enantioselective procedures for the simple and straightforward preparation of biologically andcommercially important molecules. The specific aims of this project involve the development of catalyticreactions using bismuth(III) salts. We wish to explore the catalytic effects of bismuth salts because bismuth isa cheap and non-toxic element. Moreover, Lewis acids able to catalyze enantioselective reactions under mildand environmentally benign conditions represent an extraordinary challenge for the synthetic chemist.The innovative element of this project is the development of catalytic enantioselective reactions usingbismuth(III) salts. Very limited examples have appeared in the literature involving catalytic asymmetric Mukaiyama aldol reactions. In this context, there is clearly a need for the development of new chiral bismuth(III) catalysts that are cheap, easy to handle, and sufficiently Lewis acidic. We wish to extend the development of a bismuth(III) based enantioselective procedure to the Mannich-type reaction.The project presented here falls within a research field of asymmetric organic synthesis using a bismuth(III) catalyst. This field is of significant importance as it has placed Canada at a level of excellence in the pharmaceutical and fine chemistry industry. Our proposed research program will contribute to the training of highly specialized personnel in the sectors of synthetic organic and medicinal chemistry.