Micro-ultracentrifuge and rotors

这项申请是为了一个微型超速离心机，将支持西安大略大学微生物和免疫学系传染病研究组5名成员的研究活动。这些研究人员是C.Creuzenet博士、D.Heinrichs、L.Hertel、S.Kim和M.Valvano。这些研究人员正在调查有关细菌和病毒致病性的基本问题。微型超速离心机的设计目的是允许对小规模样品进行处理，以便将其分离成各种细胞组分，如膜、细胞质或周质组分。这些细胞分级对于描述参与蛋白质分泌、蛋白质糖基化或糖脂合成等基本过程的蛋白质机械的细胞位置非常重要，这些过程都会影响细菌和病毒诱发疾病的能力。因此，除了加强我们对这些过程的基本了解外，所要求的仪器还将支持可能导致新的治疗开发的研究。

This application is for a Micro-ultracentrifuge that will support the research activities of 5 members of the Infectious Diseases Research Group of the Department of Microbiology and Immunology at the University of Western Ontario. These researchers are Drs C. Creuzenet, D. Heinrichs, L. Hertel, S. Kim and M. Valvano. These researchers are investigating fundamental questions regarding bacterial and viral pathogenicity. The micro-ultracentrifuge is designed to allow processing of small scale samples for their separation into various cellular fractions, such a membranous, cytoplasmic or periplasmic fractions. These cellular fractionations are important to delineate the cellular location of proteic machineries involved in fundamental processes such as protein secretion, protein glycosylation or glycolipid synthesis, which all impact on the ability of bacteria and viruses to induce disease. Hence, in addition to enhancing our fundamental understanding of these processes, the requested instrument will support research that might lead to novel therapeutic development.