Gas chromatograph with autosampler

这是一种用于研究金属催化有机反应的机理、动力学和结果的分析仪器的应用。气相色谱（GC）是有机和有机金属研究中常见和必不可少的工具，是表征和定量分子的有力工具，即使这些分子与其他化合物混合存在。GC仪器将用于研究新型合环复分解催化剂的效率和选择性（包括对映体选择性），合环复分解是目前构建环状分子最有效的方法之一，但存在催化剂选择性和寿命有限的问题。这也将使我们能够研究串联催化反应的效率，在串联催化反应中，我们通过原位转化催化剂，通过单一催化剂前驱体进行有机分子的顺序转化。这些方法在材料设计中已经很重要了：我们相信，耦合复分解与功能化催化将开辟新的、高效的、更环保的途径，以达到在制药和其他领域重要的有机目标。所要求的仪器将消除我们研究中的一个主要瓶颈：我们目前依赖于访问属于另一个研究小组的气相色谱，该气相色谱正在全速运行，由于其相对复杂性，因此分析我们的许多样品的能力有限。

This is an application for an analytical instrument to be used in research on the mechanisms, kinetics, and outcome of metal-catalyzed organic reactions. Gas chromatography (GC), a common and essential tool in organic and organometallic research, is a powerful tool for characterizing and quantifying molecules even where these are present as mixtures with other compounds. The GC instrument will be used to study the efficiency and selectivity (including enantioselectivity) of new catalysts for ring-closing metathesis, one of the most powerful methods now available for construction of cyclic molecules, which yet suffers from limited catalyst selectivity and lifetime. It will also allow us to study the efficiency of tandem catalysis reactions, in which we carry out sequential transformations of organic molecules via a single catalyst precursor, by transforming the catalyst in situ. These methodologies are already important in materials design: we believe that coupling metathesis with functionalization catalysis will open up new, highly efficient, environmentally more benign routes to organic targets important in pharma and elsewhere.The requested instrument will eliminate a major bottleneck in our research: we presently rely on access to a GC belonging to another research group, which is operating at capacity, and which is limited in its ability to analyze many of our samples owing to their relative complexity, and hence involatility.