Repair of epigenetic abnormalities in human induced pluripotent stem cells by targeted epigenome engineering

新的进展使患者的细胞能够重新编程为成年干细胞，有能力转变为任何特定类型的细胞，以取代患者受损的细胞。然而，我们发现成体干细胞是有缺陷的，它们对过去特化形式的表观遗传记忆限制了它们转化为其他特化细胞的能力。我们将使用一种新的分子工具来消除这种记忆，从而修复成人干细胞，使其用于再生医学。

New advances enable a patient’s cells to be reprogrammed into an adult stem cell, with the capacity to turn into any specialized cell type to replace a patient’s damaged cells. However, we have discovered that adult stem cells are flawed, they have an epigenetic memory of their past specialized form that limits their capacity to transform into other specialized cells. We will use a novel molecular tool to erase this memory, thus repairing adult stem cells for their use in regenerative medicine.