The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis
The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis
批准号:
nhmrc : 545906
负责人:
A/Pr Ian Smyth
金额:
$34.43万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
我们已经证明,一种名为ABCA12的蛋白质可以控制脂质在我们体内的运输。如果该基因的功能减弱,人类和小鼠都会患上严重的皮肤病。我们的初步结果表明,ABCA12蛋白特别调节胆固醇的运输,这笔赠款将调查这可能如何影响正常的皮肤功能,并导致心脏病动脉粥样硬化,这是西方世界最常见的死亡原因之一。
英文摘要
We have shown that a protein called Abca12 can control the transport of lipids in our bodies. If the function of this gene is attenuated both human and mice develop severe skin disease. Our preliminary results indicate the Abca12 protein regulates cholesterol transport in particular, and this grant will investigate how this might affect normal skin function and contribute to the heart disease atherosclerosis, one of the most common causes of death in the western world.
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海外基金