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Role of plasmepsin V and PTEX complex in Plasmodium liver infection

Role of plasmepsin V and PTEX complex in Plasmodium liver infection
血浆蛋白酶 V 和 PTEX 复合物在疟原虫肝脏感染中的作用
批准号:
nhmrc : 1139153
负责人:
A/Pr Justin Boddey
金额:
$57.36万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
翻译
Plasmepsin V和PTEX是疟原虫在红细胞内生长的必需蛋白质。这些蛋白质控制寄生虫蛋白质出口到红细胞,引起疾病。在红细胞被感染之前,寄生虫会侵入肝细胞。Plasmepsin V和PTEX在肝脏感染期间表达,但其功能目前尚不清楚。我们假设它们允许寄生虫将蛋白质输出到肝细胞中以存活,因此是抗疟疾药物的靶点。
英文摘要
Plasmepsin V and PTEX are essential proteins for malaria parasites to grow inside red blood cells. These proteins control the export of parasite proteins into red cells, causing disease. Before red blood cells are infected, parasites invade liver cells. Plasmepsin V and PTEX are expressed during liver infection but their function is currently unknown. We hypothesise that they allow parasites to export proteins into liver cells in order to survive and, thus, are antimalarial drug targets.
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Role of plasmepsin V and PTEX complex in Plasmodium liver infection
  • 批准号:
    nhmrc : GNT1139153
  • 项目类别:
    Project Grants
  • 资助金额:
    $84.84万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Justin Boddey
  • 依托单位:
The role of protein glycosylation in the malaria parasite
The role of protein glycosylation in the malaria parasite
  • 批准号:
    nhmrc : GNT1139546
  • 项目类别:
    Project Grants
  • 资助金额:
    $64.44万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Justin Boddey
  • 依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
  • 批准号:
    nhmrc : GNT1135421
  • 项目类别:
    Development Grants
  • 资助金额:
    $68.39万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Justin Boddey
  • 依托单位:
海外基金