The role of subcapsular sinus macrophages in lymph node metastases
The role of subcapsular sinus macrophages in lymph node metastases
批准号:
nhmrc : 1004632
负责人:
A/Pr Tri Phan
金额:
$30.07万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
该项目通过在小鼠模型和人类黑色素瘤患者中进行互补研究,解决了淋巴结转移的问题。它采用了一种新的方法来检查淋巴结中的局部地理因素,并将重点放在一种称为被膜下窦巨噬细胞的罕见细胞上,这可能是临床结果的关键决定因素。这将导致不仅对黑色素瘤而且对其他癌细胞转移的初级预防的创新策略。
英文摘要
This project tackles the problem of lymph node metastases using complementary studies in mouse models and human patients with melanoma. It takes the novel approach of examining the local geographical factors in the lymph node and focusses on a rare cell called the subcapsular sinus macrophage that may be a critical determinant of the clinical outcome. This will result in innovative strategies for primary prevention of not only melanoma but other cancer cell metastases.
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