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The role of the suppressors of cytokine signalling 6 and 7 in cerebral cortex development

The role of the suppressors of cytokine signalling 6 and 7 in cerebral cortex development
细胞因子信号6和7抑制剂在大脑皮层发育中的作用
批准号：
nhmrc : 637346
负责人：
A/Pr Anne Voss
金额：
$25.15万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2010
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2010-01-01 至 2012-12-31
来源：
https://researchdata.edu.au/role-suppressors-cytokine-cortex-development/80897
关键词：
rolesuppressorscytokinesignallingcerebral

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中文摘要
翻译
胚胎发育过程中神经细胞迁移缺陷会导致智力低下和癫痫。虽然神经元迁移对于正常智力的发展是必不可少的，但我们对调控这一过程的分子机制知之甚少。我们已经确定了两种蛋白质，SOCs6和SOCS7，它们对神经元迁移和正常大脑皮层发育是必不可少的。我们建议全面研究SOCS6和SOCS7在皮质发育过程中的功能。
英文摘要
Defects in neuronal cell migration during embryonic development lead to mental retardation and epilepsy. Although neuronal migration is essential for the development of normal intelligence, we know relatively little about the molecular mechanisms that regulate this process. We have identified two proteins, Socs6 and Socs7, which are essential for neuronal migration and normal cerebral cortex development. We propose to fully investigate the function of Socs6 and Socs7 during cortex development.
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会议论文
The molecular and biological roles of growth inhibiting chromatin binding proteins
  • 批准号：
    nhmrc : GNT1143612
  • 项目类别：
    Project Grants
  • 资助金额：
    $81.48万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Anne Voss
  • 依托单位：
The molecular and biological roles of growth inhibiting chromatin binding proteins
Regulation of haematopoietic stem cells through histone modifications
Chromatin regulation of neural stem cell multipotency
海外基金