The role of Zeta and Omega class glutathione transferases in endobitic and xenobiotc metabolism

谷胱甘肽转移酶是一种在保护细胞免受环境中有害化学物质伤害方面发挥重要作用的酶。虽然一些被谷胱甘肽转移酶解毒的化学物质会导致癌症和其他疾病，但这些酶也会消除一些用于化疗的药物。细胞中谷胱甘肽转移酶的类型和数量的变化可以使正常细胞对致癌化学物质敏感，并使癌细胞对抗癌药物产生抗药性。我们发现了两种新形式的谷胱甘肽转移酶，称为Zeta和Omega。即将在这里进行的新研究旨在了解这些新酶在抵御外来化学物质方面的作用，以及这些酶在正常细胞新陈代谢中所起的作用。因为Zeta类谷胱甘肽转移酶是旨在消除过量氨基酸酪氨酸的途径的一部分，我们将确定它的抑制是否会为一种名为遗传性酪氨酸血症的疾病患者提供一种新的治疗方法。我们还将研究决定细胞产生Zeta和Omega谷胱甘肽转移酶数量的遗传和环境因素

The glutathione transferases are enzymes that play a significant role in the protection of cells from harmful chemicals in the environment. While some of the chemicals that are detoxified by glutathione transferases cause cancer, and other diseases, these enzymes also eliminate some of the drugs that are used in chemotherapy. Variations in the type and amount of glutathione transferase in a cell can make a normal cell susceptible to cancer causing chemicals and make a cancer cell resistant to anti cancer drugs. We have discovered two new forms of glutathione transferase called Zeta and Omega. The new research to be undertaken here is aimed at understanding the role of these new enzymes in protection against foreign chemicals and the role these enzymes play in normal cellular metabolism. Because the Zeta class glutathione transferase is part of a pathway designed to eliminate excessive amounts of the amino acid tyrosine, we will determine if its inhibition will provide a new treatment for patients with a disease called hereditary tyrosinemia. We will also study the genetic and environmental factors that determine the amount of Zeta and Omega glutathione transferase produced in cells