Modelling cytoskeleton networks

细胞骨架是结构蛋白的复杂排列：微丝、中间丝和微管。它们中的每一个都有特定的物理属性和空间组织，以及在单元中的特定角色。网络的组织是其蜂窝功能的主要决定因素。此外，这三个细胞骨架网络处于持续的动态相互作用中，这决定了细胞中的许多机制。细胞骨架组织的缺陷与许多疾病的发病机制有关，如神经退行性疾病。我打算开发一个数学和计算模型框架来研究细胞骨架组织过程的动力学。动态系统的形式主义以及基于主体的模型将被用来对组织过程进行建模。模型将描述三个相互连接的细胞骨架网络。它们将考虑这些元素的生化和物理性质以及它们的相互作用，以定义整个集成系统。这个模型框架将被证明是一个非常有效的工具来研究细胞骨架蛋白和/或其相关蛋白的组装或运输中的缺陷的不同假说，这些缺陷通常是许多疾病的细胞病理学特征。

The cytoskeleton is a complex arrangement of structural proteins: microfilaments, intermediates filaments, and microtubules. Each of them has specific physical properties and spatial organizations as well as particular roles in the cell. The organization of the networks is a main determinant of their cellular function. Furthermore the three cytoskeleton networks are in constant dynamic interactions that determine many mechanisms in the cell. Defaults in the cytoskeleton organization are involved in the pathogenesis of many diseases such as neurodegenerative disorders. I intend to develop a mathematical and computational modelling framework to study the dynamics of cytoskeleton organization processes. The formalism of dynamical systems as well as agent-based models will be used to model the organizational processes. Models will describe the three interconnected cytoskeletal networks. They will account for both the biochemical and physical properties of these elements and their interactions to define the whole integrated system. This modelling framework will prove a very efficient tool to study different hypotheses of defects in the assembly or the transport of cytoskeletal proteins, and/or their associated proteins that often are cytopathological features in many diseases.