Structural biology and therapeutic targeting of proteins involved in infection and immunity
Structural biology and therapeutic targeting of proteins involved in infection and immunity
批准号:
nhmrc : 1110971
负责人:
Prof Bostjan Kobe
金额:
$51.94万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2020-12-31
中文摘要
结构生物学在揭示蛋白质在分子水平上的功能方面发挥着至关重要的作用,并进一步促进了针对这些蛋白质所涉及的疾病的治疗策略的开发。在拟议的工作中,我将专注于细菌毒力因子,开发新的抗生素和疫苗接种策略,以及参与先天免疫途径的蛋白质,以开发针对包括慢性炎症性疾病在内的一些相关疾病的治疗方法。
英文摘要
Structural biology plays an essential role in uncovering how proteins function at the molecular level, and further facilitates strategies to develop therapeutics targeting the diseases these proteins are involved in. In the proposed work, I will focus on bacterial virulence factors, to develop new antibiotics and vaccination strategies, and proteins involved in innate immunity pathways, to develop therapeutics against a number of associated disorders including chronic inflammatory diseases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Nanocrystal Electron Diffraction Facility
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批准号:LE230100145
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$75.31万
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财政年份:2023
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负责人:Prof Bostjan Kobe
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依托单位:
Structural basis of plant immune receptor signaling
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批准号:DP220102832
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项目类别:Discovery Projects
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资助金额:$36.02万
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财政年份:2022
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负责人:Prof Bostjan Kobe
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依托单位:
Unifying mechanisms of innate immunity signaling in animals and plants
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批准号:FL180100109
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项目类别:Australian Laureate Fellowships
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资助金额:$195.52万
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财政年份:2019
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负责人:Prof Bostjan Kobe
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依托单位:
Molecular mechanisms of signalling by plant immune receptors
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批准号:DP190102526
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项目类别:Discovery Projects
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资助金额:$37.8万
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财政年份:2019
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负责人:Prof Bostjan Kobe
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依托单位:
Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology
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批准号:LE180100179
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$212.64万
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财政年份:2018
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology and therapeutic targeting of proteins involved in infection and immunity
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批准号:nhmrc : GNT1110971
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项目类别:Research Fellowships
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资助金额:$75.33万
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财政年份:2016
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负责人:Prof Bostjan Kobe
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依托单位:
Molecular mechanism of action of plant immune receptors
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批准号:DP160102244
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项目类别:Discovery Projects
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资助金额:$24.54万
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财政年份:2016
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负责人:Prof Bostjan Kobe
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依托单位:
Protein glycan interactions in infectious diseases.
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批准号:nhmrc : GNT1071659
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项目类别:Programs
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资助金额:$879.58万
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财政年份:2015
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负责人:Prof Bostjan Kobe
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依托单位:
Protein glycan interactions in infectious diseases.
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批准号:nhmrc : 1071659
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项目类别:Program Grants
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资助金额:$612.27万
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财政年份:2015
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负责人:Prof Bostjan Kobe
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依托单位:
Understanding the molecular function of plant disease resistance proteins, pathogen effectors and their interaction to protect Australian agriculture
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批准号:DP120100685
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项目类别:Discovery Projects
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资助金额:$26.52万
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财政年份:2012
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology of infection and immunity
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批准号:nhmrc : 1003325
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项目类别:Research Fellowships
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资助金额:$44.31万
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财政年份:2011
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负责人:Prof Bostjan Kobe
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依托单位:
Molecular basis of the interaction between plant disease resistance proteins and pathogen avirulence proteins
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批准号:DP0984827
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项目类别:Discovery Projects
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资助金额:$20.8万
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财政年份:2009
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负责人:Prof Bostjan Kobe
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依托单位:
Functional and structural characterisation of Defective embryo and meristems (Dem) proteins involved in plant development.
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批准号:DP0559710
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项目类别:Discovery Projects
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资助金额:$18.02万
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财政年份:2005
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负责人:Prof Bostjan Kobe
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依托单位:
New approaches to functional and structural genomics
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批准号:FF0561371
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项目类别:Federation Fellowships
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资助金额:$108.92万
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财政年份:2005
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology
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批准号:nhmrc : 252736
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项目类别:NHMRC Research Fellowships
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资助金额:$30.21万
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财政年份:2003
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负责人:Prof Bostjan Kobe
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依托单位:
Molecular basis of dengue virus-induced fusion
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批准号:nhmrc : 252739
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项目类别:NHMRC Project Grants
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资助金额:$27.36万
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财政年份:2003
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负责人:Prof Bostjan Kobe
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依托单位:
Structural studies of plant disease resistance proteins
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批准号:DP0208353
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项目类别:Discovery Projects
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资助金额:$22.21万
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财政年份:2002
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负责人:Prof Bostjan Kobe
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依托单位:
Structural characterisation of phosphopeptide recognition by FHA domains
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批准号:nhmrc : 143013
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项目类别:NHMRC Project Grants
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资助金额:$17.14万
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财政年份:2001
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负责人:Prof Bostjan Kobe
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依托单位:
Structural characterisation of nuclear localisation signal-receptor recognition
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批准号:nhmrc : 991554
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项目类别:NHMRC Project Grants
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资助金额:$13.37万
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财政年份:1999
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负责人:Prof Bostjan Kobe
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依托单位:
国内基金
海外基金
组蛋白乙酰化修饰ATG13激活自噬在牵张应力介导骨缝Gli1+干细胞成骨中的机制研究
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批准号:82370988
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项目类别:面上项目
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资助金额:48.00万元
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批准年份:2023
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负责人:经典
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依托单位:
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位:
Computational Methods for Analyzing Toponome Data
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批准号:60601030
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项目类别:青年科学基金项目
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资助金额:17.0万元
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批准年份:2006
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负责人:Axel Mosig
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依托单位: