Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)
Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)
批准号:
nhmrc : 491017
负责人:
A/Pr Ashley Mansell
金额:
$36.16万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
乙肝病毒感染是一个世界性的重大健康问题,目前的治疗策略并不理想。因此,了解乙肝病毒如何与免疫系统相互作用,对于制定干预策略以促进更好的健康结果至关重要。这笔赠款将发展我们的新发现,即由乙肝病毒产生的一种蛋白质通过产生一种阻止先天免疫反应的蛋白质,使乙肝病毒能够不受挑战地复制,从而使宿主免疫系统“失明”。
英文摘要
Hepatitis B virus (HBV) infection is a major world-wide health problem, which the current treatment strategies are not ideal. Therefore understanding how HBV inteacts with the immune system is of critical importance to developing intervention strategies to promote better health outcomes. This grant will develop our novel findings that a protein produced by HBV 'blinds' the host immune system by producing a protein that blocks the innate immune response to allow HBV to replicate unchallenged.
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会议论文
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海外基金