Translational Research Program to Advance Clinical Outcomes in Acute Myeloid Leukaemia
Translational Research Program to Advance Clinical Outcomes in Acute Myeloid Leukaemia
批准号:
nhmrc : 1141460
负责人:
A/Pr Andrew Wei
金额:
$27.89万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Practitioner Fellowships
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2022-12-31
中文摘要
急性髓性白血病(AML)的五年生存率仅为27%,是临床结局最差的癌症之一。将通过实施转化研究计划来改善患者结局,以支持新药试验、早期和随机临床试验以及国家临床登记处来审计结局。对白血病干细胞功能和耐药机制的新见解将为未来临床试验的设计提供信息。
英文摘要
Five-year survival in acute myeloid leukaemia (AML) is only 27%, placing it amongst the worst-ranked cancers for clinical outcome. Improved patient outcomes will be achieved through implementation of a Translational Research Program to support novel agent drug testing, early-phase and randomised clinical trials and a national clinical registry to audit outcomes. New insights into leukaemic stem cell function and mechanisms of drug resistance will inform the design of future clinical trials.
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会议论文
Examining the contribution of mutant DNMT3a in the development and sustained growth of Acute Myeloid Leukaemia
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批准号:nhmrc : GNT1145728
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项目类别:Project Grants
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资助金额:$82.09万
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财政年份:2018
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负责人:A/Pr Andrew Wei
-
依托单位:
Examining the contribution of mutant DNMT3a in the development and sustained growth of Acute Myeloid Leukaemia
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批准号:nhmrc : 1145728
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项目类别:Project Grants
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资助金额:$55.5万
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财政年份:2018
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负责人:A/Pr Andrew Wei
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依托单位:
Toward effective targeted therapies for Acute Myeloid Leukaemia (AML)
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批准号:nhmrc : GNT1126843
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项目类别:Project Grants
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资助金额:$55.13万
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财政年份:2017
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负责人:A/Pr Andrew Wei
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依托单位:
Toward effective targeted therapies for Acute Myeloid Leukaemia (AML)
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批准号:nhmrc : 1126843
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项目类别:Project Grants
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资助金额:$37.58万
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财政年份:2017
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负责人:A/Pr Andrew Wei
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依托单位:
Eradicating leukaemic stem cells by targeting the arginine methyltransferase PRMT5
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批准号:nhmrc : 1086662
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项目类别:Project Grants
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资助金额:$51.41万
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财政年份:2015
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负责人:A/Pr Andrew Wei
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依托单位:
Targeting IAPs in Leukaemias using the Smac-mimetic drug Birinapant
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批准号:nhmrc : 1081376
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项目类别:Project Grants
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资助金额:$64.63万
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财政年份:2015
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负责人:A/Pr Andrew Wei
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依托单位:
Eradicating leukaemic stem cells by targeting the arginine methyltransferase PRMT5
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批准号:nhmrc : GNT1086662
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项目类别:Project Grants
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资助金额:$74.24万
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财政年份:2015
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负责人:A/Pr Andrew Wei
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依托单位:
Targeting IAPs in Leukaemias using the Smac-mimetic drug Birinapant
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批准号:nhmrc : GNT1081376
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项目类别:Project Grants
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资助金额:$93.25万
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财政年份:2015
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负责人:A/Pr Andrew Wei
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依托单位:
Targeting the apoptosis machinery in cancer
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批准号:nhmrc : GNT1066711
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项目类别:Project Grants
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资助金额:$52.79万
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财政年份:2014
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负责人:A/Pr Andrew Wei
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依托单位:
Targeting the apoptosis machinery in cancer
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批准号:nhmrc : 1066711
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项目类别:Project Grants
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资助金额:$36.41万
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财政年份:2014
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负责人:A/Pr Andrew Wei
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依托单位:
A randomised study to optimise clinical outcomes in patients with FLT3 mutant AML
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批准号:nhmrc : 1048312
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项目类别:Project Grants
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资助金额:$77.99万
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财政年份:2013
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负责人:A/Pr Andrew Wei
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依托单位:
GADD45A promoter methylation and poor prognosis in AML:mechanism and clinical significance
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批准号:nhmrc : 1024342
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项目类别:Project Grants
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资助金额:$47.09万
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财政年份:2012
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负责人:A/Pr Andrew Wei
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依托单位:
Dual inhibition of independent cell survival pathways as a new approach for targeting leukemic stem cells
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批准号:nhmrc : 1032248
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项目类别:Project Grants
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资助金额:$37.52万
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财政年份:2012
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负责人:A/Pr Andrew Wei
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依托单位:
国内基金
海外基金
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