Structure, biosynthesis, and function of bile acids in C. elegans
Structure, biosynthesis, and function of bile acids in C. elegans
批准号:
252035
负责人:
Hekimi Siegfried
金额:
$42.16万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-03-01 至 2017-03-01
中文摘要
在目前的拨款申请中,我建议使用动物模型来理解为什么导致心血管疾病的一些风险因素优先发生在老年人身上。这些经常同时发生的危险因素是肥胖、糖尿病
英文摘要
In the present grant application I propose to use an animal model to understand why some of the risk factors that lead to cardiovascular diseases develop preferentially in aged individuals. These risk factors, which often occur together, are obesity, diab
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会议论文
Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
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批准号:379736
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项目类别:Operating Grants
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资助金额:$50.16万
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财政年份:2018
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负责人:Hekimi Siegfried
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依托单位:
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
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批准号:368962
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资助金额:$222.05万
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财政年份:2017
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负责人:Hekimi Siegfried
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依托单位:
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
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批准号:320289
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项目类别:Operating Grants
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资助金额:$47.53万
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财政年份:2015
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负责人:Hekimi Siegfried
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依托单位:
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
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批准号:304014
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项目类别:Operating Grants
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资助金额:$45.33万
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财政年份:2014
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负责人:Hekimi Siegfried
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依托单位:
C. elegans models of mitochondrial deficiency in the nervous system
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批准号:235523
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项目类别:Operating Grants
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资助金额:$8.74万
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财政年份:2011
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负责人:Hekimi Siegfried
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依托单位:
Mechanisms of longevity in C. elegans mutants with defective mitochondria.
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批准号:223894
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项目类别:Operating Grants
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资助金额:$34.98万
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财政年份:2011
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负责人:Hekimi Siegfried
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依托单位:
Molecular and physiological mechanisms of longevity in Mclk1+/- mutants
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批准号:179427
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项目类别:Operating Grants
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资助金额:$45.42万
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财政年份:2009
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负责人:Hekimi Siegfried
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依托单位:
海外基金