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Identification and processing of slipped-DNAs in patient tissues: Mutagenic Intermediates of Disease-Associated CAG/CTG Trinucleotide Repeat Instability

Identification and processing of slipped-DNAs in patient tissues: Mutagenic Intermediates of Disease-Associated CAG/CTG Trinucleotide Repeat Instability
患者组织中滑脱 DNA 的鉴定和处理：疾病相关 CAG/CTG 三核苷酸重复不稳定性的诱变中间体
批准号：
172704
负责人：
Pearson Christopher E
金额：
$70.11万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2008
资助国家：
加拿大
项目状态：
已结题
起止时间：
2008-09-01 至 2013-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=172704&lang=en
关键词：
Dna Mutation Dna Repair Dna Replication Dna Structure Genetic Instability Genome Stability

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中文摘要
翻译
包括强直性肌营养不良在内的大约40种人类疾病是以这样一种方式遗传的，即症状会在几代人中变得更糟，并且随着个体年龄的增长而恶化。这些疾病是由涉及重复DNA序列的DNA突变引起的。如果
英文摘要
About 40 human diseases, including myotonic dystrophy, are inherited in a manner that the symptoms become worse down generations as well as worsening as the individual ages. These diseases are caused by DNA mutations involving repeated DNA sequences. If
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