Biointerface science: proteoglycan 4 (PRG4) with and without hyaluronic acid as a novel ocular surface boundary lubricant & contact lens coating

干眼病是一个主要的卫生保健问题，也是全世界卫生保健资源的消耗，其症状包括不适、眼表损伤和生活质量显著下降，目前尚无有效的治疗方法。眼表面的细胞在与对立组织或隐形眼镜滑动时形成生物界面，受到眨眼产生的巨大摩擦力的影响。佩戴隐形眼镜会加剧这些力量，尤其是在泪膜受损的情况下，这是干眼症的另一种症状。蛋白多糖4 (PRG4)，也称为润滑素，是一种最初发现于滑液和关节软骨表面的蛋白质，最近在眼表发现。PRG4已被证明以剂量依赖的方式发挥作用，无论是单独还是与透明质酸结合

Dry eye disease is a major health-care issue and drain on health-care resources worldwide, with symptoms of discomfort, damage to the ocular surface, and a significant reduction in quality of life, with no current therapeutically effective treatments. Cells at the ocular surface, which forms a biointerface when sliding against an opposing tissue or contact lens, are subject to significant friction forces generated with eyelid blinking. These forces can be exacerbated by contact lens wear particularly in the presence of a compromised tear film, another symptom of dry eye. Proteoglycan 4 (PRG4), also known as lubricin, is a protein originally discovered in synovial fluid and on the surface of articular cartilage that has recently been discovered at the ocular surface. PRG4 has been shown to function in a dose-dependent manner, both alone and in combination with hyaluronic