Bio-nanoengineering of III-V quantum semiconductor surfaces and interfaces

我的研究计划的目标是推进III-V族量子半导体表面和界面的纳米工程的基础知识。这将允许探索基于单片集成（小型化）生物光子器件的快速和准确的光子生物传感的创新技术。我的计划旨在开发一种强大的生物传感器技术，该技术对于在临床或医生办公室环境中快速检测选定的病毒和细菌病原体具有吸引力和可接受性。因此，目标不是寻找记录敏感的传感器，而是确定允许构建高度准确的生物传感器的条件。为了实现这一目标，我将利用光致发光和表面等离子体共振光谱，为表面现象和基于表面的生物传感的研究提供了一个很好的平台。建议的研究的第一轴是面向GaAs表面的硫醇和肽的生物功能化的基础研究。第二个轴地址的发展是基于适体纳米技术和量子阱SPR生物芯片在我的实验室制造的“正交生物传感器”。

The goal of my research program is to advance fundamental knowledge of nanoengineering of III-V quantum semiconductor surfaces and interfaces. This will allow for the exploration of innovative technologies of rapid and accurate photonic biosensing based on monolithically integrated (miniaturized) biophotonic devices. My program aims at the development of a robust biosensor technology that would be attractive and acceptable for rapid detection of selected viral and bacterial pathogens in the clinical or medical doctor's office environments. As such, the goal is not to seek a record sensitive transducer, but rather determine conditions that would allow for the construction of a highly accurate biosensor. To achieve this goal, I will take advantage of the photoluminescence and surface plasmon resonance spectroscopies that provide an excellent platform for the study of surface phenomena and surface-based biosensing. The first axis of the proposed research is oriented on the fundamental study of biofunctionalization of GaAs surfaces with thiols and peptides. The second axis addresses the development of an 'orthogonal biosensor' that is based on aptamer nanotechnology and quantum well SPR biochips fabricated in my laboratory.