Organofluorine chemistry: New synthetic methods and new reactivity

由于氟原子的独特性质，氟化分子在制药/医药、农化和材料科学中占有重要地位。例如，据估计，市场上多达30-40%的农用化学品和20-25%的药品含有氟。此外，氟被用于标记生化探针，用于研究各种生物过程，19F核具有核磁共振活性，甚至允许使用体内磁共振成像（MRI）。最后，18f正电子发射断层扫描（PET）每天用于诊断、分期和检测包括癌症在内的各种疾病的复发或进展。然而，这些领域以及其他领域的进一步发展与开发实用、选择性和高效的氟化分子合成方法密切相关。

Fluorinated molecules occupy a significant place in pharmaceutical/medicinal, agrochemical, and material sciencesd ue to the unique properties of the fluorine atom. For example, as many as 30-40% of agrochemicals and 20-25% of pharmaceuticals on the market are estimated to contain fluorine. Also, fluorine is used to tag biochemical probes for the study of various biological processes and the fact that 19F nuclei is NMR active even allows the use of in vivo magnetic resonance imaging (MRI). Finally, 18F-positron-emitting tomography (PET) is used daily for diagnosing, staging, and detecting the recurrence or progression of various diseases including cancer. Nevertheless, further development of these fields as well as others are closely related to the development of practical, selective and efficient methodologies for the synthesis of fluorinated molecules.