Real-time intraoperative spectroscopic tumor margin detection in robotic-assisted radical prostatectomy on prostate cancer patients

手术切除肿瘤是一线治疗方法，成功的患者预后依赖于切除尽可能多的癌细胞。ODS医疗公司开发了一种手术内系统，该系统使用手持探针精确定位癌组织，以便通过传统技术识别出的边缘切除。利用一种被称为拉曼光谱的光学效应来识别癌症的分子特征，它可以在几分之一秒内区分正常组织和癌变组织。虽然最初的演示是在大脑中进行的，但这些技术绝不仅限于脑癌。我们积累了证据，支持ODS医疗的癌症检测探针扩展到根治性前列腺切除术，根治性前列腺切除术是前列腺癌患者的重要护理标准。本多学科项目提出了分子成像（拉曼光谱和本征组织荧光）机器人平台的工程开发和术中体内评估，旨在提高机器人辅助前列腺癌根治术中前列腺癌患者的癌症检测准确性。学术申请者与ODS Medical、Intuitive Surgical、MEDTEQ、CR-CHUM和玛格丽特公主癌症中心合作开展该项目。一旦成功，该项目将提高肿瘤切除的准确性和完整性，这将对患者的生存和生活质量产生直接影响，并通过减少标准外科手术的低效率和成本来降低医疗成本。由于5个根治性前列腺切除术中有4个是使用Intuitive机器人系统进行的，因此整合光学成像技术具有巨大的潜在市场，这可以为加拿大初创公司ODS Medical创造重要的收入。该项目还将有助于使加拿大处于高科技研究的前沿。

Surgical removal of the tumor is the front-line therapy and successful patient outcomes rely on removing the most cancer cells possible. ODS Medical's has developed an intra-operative system that uses a hand-held probe to pinpoint cancerous tissue for removal past the margins identified by conventional technologies. Using an optical effect, known as Raman spectroscopy to recognize the molecular signature of cancers, it can distinguish between normal and cancerous tissue, all in a fraction of a second. While original demonstrations were done in the brain, these technologies are by no means limited to brain cancer. We accumulated evidence to support the extension of ODS Medical's cancer detecting probe to Radical Prostatectomy, an important standard of care for patients suffering from prostate cancer. This multi-disciplinary project proposes the engineering development and intraoperative in vivo evaluation of a molecular imaging (Raman spectroscopy and intrinsic tissue fluorescence) robotic platform with the goal of improving cancer detection accuracy during robotic assisted radical prostatectomy procedures on prostate cancer patients. Academic applicants have partnered with ODS Medical, Intuitive Surgical, MEDTEQ, CR-CHUM and the Princess Margaret Cancer Center for this project. Upon success, the project will improve the accuracy and completeness of tumor resections which can have a direct impact on patient survival and quality-of-life as well as lead to a reduction in healthcare costs by reducing inefficiencies and costs of standard surgical procedures. Since 4 out of 5 radical prostatectomies are performed using the Intuitive robotic system, there is a significant potential market for integrating optical imaging technologies which can create important revenue for Canadian startup ODS Medical. The project will also contribute to putting Canada at the forefront of high-tech research.