High Resolution EI Mass Spectrometer

本提案是获得一个高分辨率的EI质谱计，用于分析非极性有机化合物和有机金属。质谱法是一种强大的分析技术，用于鉴定未知化合物，定量已知化合物，并阐明分子的结构和化学性质。质谱法已经应用于许多领域，包括药物发现和材料化学。它是一种分析技术，不仅应用于化学领域，而且应用于更广泛的领域。合成化学家用它来确认新化合物的化学合成，天然产物化学家用它来阐明天然产物的结构。质谱仪是一种可以测量转化为离子的单个分子质量的仪器。它可以被看作是一种用来称分子重量的机器。用质谱仪测量化合物的质量，并与化合物的理论质量相匹配，就可以确定化合物的性质。不同的电离技术和质量分析仪可用于分析不同类型的化合物。非极性小分子电离的最佳方法是电子冲击电离。具有电子冲击（EI）电离源的高分辨率质谱仪对于提供非极性化合物的高精度质量测量特别有用。精确的质量数据和足够的精度被用来确认或确定化合物的元素组成（EC）。元素组成的测定是合成化合物鉴定或新型天然产物结构鉴定的关键步骤。这台仪器将取代一台使用了42年、目前正在失效的主力仪器。迫切需要新的仪器来推进PI和共同申请人以及UBC和该地区的其他用户的研究。该仪器将由化学系的12个研究小组和BC省更广泛社区的许多其他研究小组使用。

This proposal is to obtain a high resolution EI mass spectrometer for the analysis of non-polar organic compounds and organometallics. Mass spectrometry is a powerful analytical technique that is used to identify unknown compounds, to quantify known compounds, and to elucidate the structure and chemical properties of molecules. Mass spectrometry has been used in many areas including drug discovery and material chemistry. It is an analytical technique used in not only chemistry area but very broader areas. It has been used by synthetic chemists to confirm their chemical synthesis of new compounds and natural product chemists for structure elucidation of natural products. A mass spectrometer is an instrument that can measure the masses of individual molecules that have been converted into ions. It can be viewed as a machine used to weigh molecules. A compound can be identified by measuring the mass using mass spectrometer and matching with the theoretical mass of the compound. Different ionization techniques and mass analyzers are available for analyzing different type of compounds. Non-polar small molecule are best ionized by electron impact (EI) ionization. A high resolution mass spectrometer with electron impact (EI) ionization source is particularly useful for providing mass measurements at very high accuracy for non-polar compounds. Accurate mass data with enough accuracy are used to confirm or determine the elemental composition (EC) of the compounds. Elemental composition determination is a critical step for synthetic compound identification or structure elucidation of novel natural product. This instrument will replace a 42 year old workhorse instrument that is currently failing. The new instrument is critically needed to advance the research of the PI and co-applicants as well as other users from UBC and the region. This instrument will be used by 12 research groups in the Chemistry Department and many others from broader community in BC.