Real-time intraoperative spectroscopic tumor margin detection in robotic-assisted radical prostatectomy on prostate cancer patients

手术切除肿瘤是一线治疗，成功的患者预后取决于尽可能切除最多的癌细胞。消耗臭氧层物质医疗公司开发了一种术中系统，该系统使用手持探头来精确定位癌症组织，以超过传统技术确定的边缘进行切除。利用一种名为拉曼光谱的光学效应来识别癌症的分子特征，它可以在一秒钟内区分正常组织和癌症组织。虽然最初的演示是在大脑中完成的，但这些技术绝不限于脑癌。我们积累了证据，支持将ods Medical的癌症检测探头扩展到前列腺癌根治术，这是前列腺癌患者的重要护理标准。这一多学科项目提出了分子成像(拉曼光谱和固有组织荧光)机器人平台的工程开发和手术中的体内评估，目的是提高机器人辅助前列腺癌根治术的癌症检测精度。学术申请者已经与消耗臭氧层物质医疗、直觉外科、MEDTEQ、CR-CHUM和玛格丽特公主癌症中心为这个项目进行了合作。一旦成功，该项目将提高肿瘤切除的准确性和完整性，这可能对患者的生存和生活质量产生直接影响，并通过减少标准手术程序的低效和成本来降低医疗成本。由于五分之四的根治性前列腺切除术是使用直观的机器人系统进行的，因此集成光学成像技术有一个巨大的潜在市场，可以为加拿大初创公司ods Medical创造重要的收入。该项目还将有助于使加拿大走在高科技研究的前沿。

Surgical removal of the tumor is the front-line therapy and successful patient outcomes rely on removing the most cancer cells possible. ODS Medical's has developed an intra-operative system that uses a hand-held probe to pinpoint cancerous tissue for removal past the margins identified by conventional technologies. Using an optical effect, known as Raman spectroscopy to recognize the molecular signature of cancers, it can distinguish between normal and cancerous tissue, all in a fraction of a second. While original demonstrations were done in the brain, these technologies are by no means limited to brain cancer. We accumulated evidence to support the extension of ODS Medical's cancer detecting probe to Radical Prostatectomy, an important standard of care for patients suffering from prostate cancer. This multi-disciplinary project proposes the engineering development and intraoperative in vivo evaluation of a molecular imaging (Raman spectroscopy and intrinsic tissue fluorescence) robotic platform with the goal of improving cancer detection accuracy during robotic assisted radical prostatectomy procedures on prostate cancer patients. Academic applicants have partnered with ODS Medical, Intuitive Surgical, MEDTEQ, CR-CHUM and the Princess Margaret Cancer Center for this project. Upon success, the project will improve the accuracy and completeness of tumor resections which can have a direct impact on patient survival and quality-of-life as well as lead to a reduction in healthcare costs by reducing inefficiencies and costs of standard surgical procedures. Since 4 out of 5 radical prostatectomies are performed using the Intuitive robotic system, there is a significant potential market for integrating optical imaging technologies which can create important revenue for Canadian startup ODS Medical. The project will also contribute to putting Canada at the forefront of high-tech research.