Etudes des mécanismes de l'adaptation et des relations interneuronales au cortex.

*在上一个周期中，我的实验室*调查了两个主题。A)适应对视觉皮层偏好刺激变化的影响我们的发现为探索神经元和神经元网络的可塑性提供了机会。B)形成连接体的神经元之间的功能关系。本课题提出了对神经元信号进行编码的过程。我们的研究计划旨在进一步发展上述创新课题，以了解中枢神经系统可塑性的基本机制和群体编码的动力学。我们建议的程序涉及两个最热门的*主题：连接体的可塑性和动力学。*实验是在*麻醉动物身上进行的。电极矩阵被降至大脑皮层。将研究以下特定主题。*A)初始刺激对后续刺激所引起的反应的影响。刺激留下痕迹。*在初始阶段，我们应用两种类型的刺激。第一个条件性短刺激是恒定的，也就是说，*表现出相同的属性，第二个条件性*刺激(相同类型)投射出可变的属性，例如方向。条件性刺激之后，每隔一段时间就会有一个测试刺激。假设是每个条件刺激如何影响对测试刺激的反应？

* **During the last cycle my lab*investigated two themes. A) The influence of adaptation on changes of*preferred stimulus in visual cortex; our findings point to opportunities to explore plasticity of*neurons and neuronal networks. B) The functional*relationships between neurons forming a connectome. This topic suggests*a process of encoding neuronal signals.***Our research program aims to further develop*the above innovative topics in order to understand fundamental *mechanisms of plasticity and the dynamics of population encoding in the CNS. Our proposed program deals with the two hottest*topics: plasticity and dynamics of connectomes. ***Experiments are carried out on*anesthetized animals. Electrode matrices are lowered into the cortex. The*following specific subjects will be investigated.***A) Influence of an initial stimulus upon responses evoked*by a following stimulus. Stimuli leave a trace.*In the initial phase we apply two types of stimuli. The first conditioning short stimulus is constant, that is,*exhibiting an identical property, the second conditioning*stimulus (same type) projects a variable property e.g.orientations. Conditioning stimuli are*followed at a predetermined interval by a test stimulus. The hypothesis is how each of the*conditioning stimuli affects the responses to the test stimulus?