Radio Frequency Identification-Assisted Intestinal Biome Sampling Device

Nimble Science Ltd.需要SAIT的帮助，为其可摄入的小肠微生物组抽吸（SIMBA）胶囊原型添加无线跟踪系统作为增值功能。SAIT将通过将射频识别（RFID）技术集成到胶囊中来解决公司面临的这一挑战，该胶囊将与采样垫沿着激活，并传输信号以无线跟踪通过消化道的采样过程的进展。小肠是宿主，药物，食物和微生物相互作用的地方。胶囊是一个两阶段的装置，在外部胶囊溶解时开始流体采样;然后在固定的时间间隔后，发生第二阶段，停止采样，并将样本机械密封，以便稍后回收。了解采样装置的启动瞬间将改善提取的数据，并实际上消除目前在其临床试验中所需的六种低剂量X射线。技术挑战是将无源RFID设备与Nimble专有的采样技术集成，以发出胶囊采样开始和停止的信号。此外，没有市售的RFID装置具有跟踪上述采样过程所需的特征。拟议项目将利用生物信息学和通信技术等新兴平台。

Nimble Science Ltd. needs SAIT's assistance to add a wireless tracking system as a value-added feature to its ingestible small intestine microbiome aspiration (SIMBA) capsule prototype. SAIT will address this company challenge by integrating radio frequency identification (RFID) technology to the capsule that will activate along with the sampling pad and transmit a signal to wirelessly track the progress of the sampling procedure through the digestive tract. The small intestine is where host, drug, food and microbiome interact. The capsule is a two-stage device that begins fluid sampling on dissolution of an outer capsule; then after a fixed interval a second stage occurs where sampling ceases and the specimen is mechanically sealed for later recovery. Knowing the instant of actuation of the sampling device will improve the extracted data and virtually eliminate the six low-dose X-rays presently needed in their clinical trials. The technical challenge is to integrate a passive RFID device with Nimble's proprietary sampling technology to signal the initiation and cessation of sampling from the capsule. In addition, there is no commercially available RFID device with the features required to track the above sampling process. The proposed project will use emerging platforms such as bioinformatics and communication technologies.