Design, developement and validation of materials and surfaces for innovative biomaterials

在过去的几十年里，生物材料已经成功地改善了数百万人的生活质量。然而，很少有生物材料和医疗设备的应用是完全成功的。失败或临床并发症经常被观察到，不同的发生率与应用有关。我提出的研究计划是一个非常坚实的基础和锚定的NSERC发现项目，研究材料科学和工程方面应用于心血管医学领域。具体而言，我建议进行并巩固一个新的3块研究计划：1)研究允许开发高附着力和强粘性涂层的参数，主要基于等离子体聚合用于金属器件；2)设计一类新的心血管设备专用的可降解金属；3)在特定的可控生物反应器中开发机械应力下材料和细胞界面的新策略，用于血管组织的再生。区块1和区块2的总体目标是在短期和中期（1至5年）提供能够改善医疗器械临床性能的新涂层和新材料。block 3的总体目标是产生有针对性的知识和专业知识，这些知识和专业知识易于在长期（10至15年）内产生用于功能性血管组织再生的特定方法。***拟议的研究计划非常相关，及时回答了形成高素质人才的需要，从而满足了精确的社会需求和医疗器械行业的挑战。此外，拟议的研究项目计划形成一个多价技术平台，可应用于其他领域和应用，包括制药、耐腐蚀、光学、民用、军事和工业，这些领域需要专门设计具有目标性能的材料和涂层。我们利用先进的材料科学和工程技术为生物医学挑战提供工程解决方案。***在这项提案中，我们既提高了知识，又为加拿大培养了关键优势领域的高素质人才。我们的研究环境是卓越的，特别适应我们现在面临的新的全球市场时代。自2008年以来，已有100多名HQP在我们的实验室接受培训：今天，他们通过使用我们培训的日常先进知识，领导力，快速适应技能，全球网络连接和战略思维，在学术界，工业界和政府中担任职务。我们的实验室被广泛认可，并在科学领域开辟了新的大门，为新发明申请专利并提出许可，出席国际会议，与四大洲的学术界和工业界的20多位世界领导人合作，并为监管政府机构提供建议。**

In the last decades, biomaterials have been successful to improve quality of the life for millions. However, very rare are the applications for which biomaterials and medical devices are completely successful. Failures or clinical complications are often observed, with different incidences related to the applications. The Research Proposal I am putting forward is a NSERC discovery program very solidly based and anchored on studying material science and engineering aspects applied to the cardiovascular medical field. ***Specifically, I propose to pursue and consolidate a new 3 blocks-research program for: 1) investigating the parameters allowing the development of a highly-adherent and strongly-cohesive coating mainly based on plasma polymerization for metallic devices; 2) designing a new class of degradable metals specific for cardiovascular devices; and 3) developing new strategies for interfacing materials and cells under mechanical stresses in specific controlled bioreactors for the regeneration of the vascular tissue. The overall goal of blocks 1 and 2 is to provide at short and medium terms (1 to 5 years) new coatings and new materials capable to improve the clinical performances of medical devices. The overall goal of block 3 is to produce targeted knowledge and expertise susceptible to generate at long terms (10 to 15 years) specific methodologies for the regeneration of the functional vascular tissue. ***The proposed research program is very pertinent and timed to answer the need of the formation of highly qualified personnel, thus fulfilling precise social needs, and medical-device industry challenges. Moreover, the proposed research program is planned to result in a polyvalent technological platform susceptible to be applied to other fields and applications, including pharmaceutical, corrosion-resistant, optical, domestic, military and industrial, where specifically-designed materials and coatings with targeted properties are required. We are engineering solutions to biomedical challenges using advanced materials science and engineering. ***In this proposal, we both advance knowledge and train high quality personnel in key areas of strength for Canada. Our research environment is exceptional and particularly adapted to the new global market era we are facing now. More than 100 HQP were trained in our laboratory since 2008: Today, they pursue positions in academia, industry and government by using daily advanced knowledge, leadership, fast adaptive skills, global network connections and strategic thinking for which they have been trained with us. Our Laboratory is recognised to publish widely and in opening new doors in Science, patent new inventions and propose licenses, present at international conferences, collaborate with some twenty world leaders in academia and industry in four continents, and provide advices to regulatory governmental agencies. **