Adapting the business model to rapidly produce and market efficacious hand sanitizing foam to combat and contain the COVID-19 outbreak

该项目的目的是开发一种温和的发泡洗手液，其杀灭引起感染的微生物的效率为99.9%，以帮助缓解个人消毒剂的短缺，并建立长期供应商以保持可获得性。我们建议配制一种以泡沫为基础的杀菌产品，并测试其致病菌致死率，在产品标签上注明“杀死99.9%的细菌”。泡沫洗手液比液体洗手液粘手效果更好，每次使用所需的量更少。有效泡沫洗手液的开发和生产将为消费者提供另一种可用的个人消毒剂选择，以减少微生物的传播，并有助于对抗COVID-19大流行。该项目将由La cit<s:1>生物创新技术准入中心开展，可以在COVID-19物理距离措施到位的情况下进行，因为已经获得了对研究设施的控制准入。为所有人员提供了额外的个人防护装备，并提供了额外的实验室空间，以遵守加拿大公共卫生署建议的物理距离。该项目的具体目标是：1)准备研究伦理批准文件并招募人类参与者；2)评估两种主要的泡沫配方类型——水基泡沫和乙醇基泡沫——在皮肤上的质地和温和程度；3)在体外测试泡沫抗病原体的效率；4)在临床试验中评估泡沫抗病原体的效率。在试验的设计和实施期间，将咨询一位加拿大卫生部条例方面的专家。这种拟议的产品将是预防传播的最基本和最具成本效益的方法之一。

The purpose of this project is to develop a gentle foaming hand sanitizer that shows 99.9% efficacy at destroying microorganisms that cause infections to help palliate the shortage of personal antiseptics and establish long-term suppliers to maintain accessibility. We propose to formulate a foam-based antiseptic product and test its efficacy of pathogen lethality to indicate 'kills 99.9% of germs' on the product label. Foaming hand sanitizers cling to hands better than liquid hand sanitizer and less of it is required per use. The development and production of an effective foaming hand sanitizer will provide another available option of personal antiseptic to consumers to reduce the transmission of microbes in general and help combat the COVID-19 pandemic. This project will be conducted by the Technology Access Center in Bio-Innovation at La Cité and can take place while the COVID-19 physical distancing measures are in place since controlled access to the research facilities have already been granted. Extra personal protective equipment (PPE) is given to all personnel and additional laboratory space has been made available to abide by the physical distancing recommended by the Public Health Agency of Canada. The specific aims of the project are to 1) prepare documents for research ethics approval and recruit human participants; 2) evaluate two major foam formulation types - water- vs ethanol-based - in terms of texture and gentleness on the skin; 3) test the efficiency of the foam against pathogens in vitro; and 4) evaluate the efficiency of the foam against pathogens in a clinical trial. An expert in Health Canada's regulations will be consulted during the design and performance of the trial. This proposed product would be one of the most fundamental and cost-effective ways of preventing transmission.