Application of the Solvatochromic Comparison Method to Chromatographic Retention and Selectivity

这个项目是在分析和表面化学的一般领域和分离科学的子领域。本实验计划的重点是阐述线性溶剂化能量关系，作为溶剂对液-液和液-气分离过程的影响的可靠预测因子，这在分析气-液色谱法和分离工程中至关重要。具体来说，控制溶质在气相和液相之间分配的基本化学因素将通过顶空气相色谱法进行研究。要检查的溶质和溶剂的选择反映了广泛的溶剂变色参数，包括双极性，氢键酸性和碱性，以及这些溶剂在分析色谱和技术相关分离过程中的使用程度。这些研究应该在现代分配平衡理论和常用的经验关系之间提供一个统一和基本健全的桥梁，并可能为合理选择系统提供基础，以便有效和经济地实现所需的分析和工业规模分离。

This project is in the general area of analytical and surface chemistry and in the subfield of separation science. The thrust of this experimental program is the elaboration of linear solvation energy relationships as reliable predictors of the effects of solvent on liquid-liquid and liquid-vapor separation processes that are critically important in analytical gas-liquid chromatography and in separations engineering. Specifically, the fundamental chemical factors controlling the partitioning of solutes between gas and liquid phases will be studied by head space gas chromatography. Solutes and solvents to be examined have been selected to reflect a broad spectrum of solvatochromic parameters including dipolarity, hydrogen bonding acidity, and basicity and the extent of utilization of these solvents in analytical chromatography and technologically relevant separations processes. These studies should provide a unifying and fundamentally sound bridge between modern partition equilibrium theory and commonly used empirical relationships and may provide a basis for the rational selection of systems with which desired analytical and industrial-scale separations could be achieved efficiently and economically.