Application of the Solvatochromic Comparison Method to Chromatographic Retention and Selectivity

溶剂致变色比较法在色谱保留和选择性中的应用

• 批准号: 9002446
• 负责人: Peter Carr
• 金额: $ 43.37万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9002446&HistoricalAwards=false
• 关键词: Application; Solvatochromic; Comparison; Method; Chromatographic

This project in the Analytical and Surface Chemistry Program of the Chemistry Division studies the fundamentals of solvation, the interaction of additives with liquids. Solvation properties affect reaction rates and the course of reactions. When two or more solvents interact, separation of components is based on competitive solvation properties. Prof. Carr has been developing general descriptions of solvation, and this work extends his earlier explorations. Solvation properties are organized based on Kamlet-Taft scales of dipolarity, hydrogen bond acidity, and basicity. Gas and liquid chromatography will be used to measure solvation parameters, and then new chromatography columns will be evaluated based on knowledge of the previously measured parameters. Extension to characterization of reversed phase liquid chromatography will be made. Free energy scales for solvation as a function of acidity and basicity parameters will be established.

该项目在分析和表面化学程序的 化学部研究溶剂化的基本原理， 添加剂与液体的相互作用。 溶剂化 性质影响反应速率和反应过程。 当两种或更多种溶剂相互作用时， 基于竞争性溶剂化性质。 卡尔教授 发展了溶剂化的一般描述，这项工作 延续了他早期的探索 溶剂化性质基于Kamlet-Taft标度进行组织 偶极性氢键酸性和碱性 气体和 液相色谱法将用于测量溶剂化 参数，然后将新的色谱柱 基于先前测量的知识进行评估 参数 反相特性的扩展 将进行液相色谱分析。 自由能尺度为 溶剂化作为酸碱度参数函数， 建立。