Application of the Solvatochromic Comparison Method to Chromatographic Retention and Selectivity

本项目隶属于化学学部的分析与表面化学项目，研究溶剂化的基本原理，添加剂与液体的相互作用。溶剂化性质影响反应速率和反应过程。当两种或两种以上溶剂相互作用时，组分的分离是基于竞争性溶剂化性质的。卡尔教授一直在发展溶剂化的一般描述，这项工作扩展了他早期的探索。溶剂化性质是根据双极性、氢键酸度和碱度的kamlett - taft尺度组织的。气相和液相色谱法将用于测量溶剂化参数，然后新的色谱柱将根据以前测量的参数的知识进行评估。将反相液相色谱法推广到表征。建立了随酸度和碱度参数变化的溶剂化自由能标度。

This project in the Analytical and Surface Chemistry Program of the Chemistry Division studies the fundamentals of solvation, the interaction of additives with liquids. Solvation properties affect reaction rates and the course of reactions. When two or more solvents interact, separation of components is based on competitive solvation properties. Prof. Carr has been developing general descriptions of solvation, and this work extends his earlier explorations. Solvation properties are organized based on Kamlet-Taft scales of dipolarity, hydrogen bond acidity, and basicity. Gas and liquid chromatography will be used to measure solvation parameters, and then new chromatography columns will be evaluated based on knowledge of the previously measured parameters. Extension to characterization of reversed phase liquid chromatography will be made. Free energy scales for solvation as a function of acidity and basicity parameters will be established.