Mathematical Sciences: Theories of Ionic Movement in Biological Channels

数学科学：生物通道中离子运动的理论

• 批准号: 9012294
• 负责人: Robert Eisenberg
• 金额: $ 11.49万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-15 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9012294&HistoricalAwards=false
• 关键词: Mathematical; Sciences; Theories; Ionic; Movement

This group of investigators will study theoretical models of ionic movement in biological channels. The theoretical models will be used in conjunction with data, to suggest new experiments, and to modify the existing model. The goal of these models is to better understand the biology. Many functions of many cells are determined by individual channel proteins, which control the movement of substances and signals across otherwise quite impermeable membranes. This group will use the theory of Brownian motion of ions in solution to analyze the experimentally known properties of ion movement in channels. The group hopes to understand and predict the large mass of experimental data describing conductance, current-voltage relations, and selectivity of single open channels of various types.

这组研究人员将研究 生物通道中的离子运动。 理论模型 将与数据结合使用，以建议新的 实验，并修改现有的模型。 这些目标 模型是为了更好地理解生物学。 的许多功能 许多细胞由单个通道蛋白决定， 控制物质和信号的移动 相当不透气的膜。 这个小组将使用 离子在溶液中布朗运动的实验分析 通道中离子运动的已知特性。 该集团希望 理解和预测大量的实验数据 描述电导、电流-电压关系，以及 各种类型的单一开放通道的选择性。