Stochastic Analysis of Ionic Channels

离子通道的随机分析

• 批准号: 9405440
• 负责人: Robert Eisenberg
• 金额: $ 12.25万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9405440&HistoricalAwards=false
• 关键词: Stochastic; Analysis; Ionic; Channels

9405440 Eisenberg The subject of this award is the theoretical study of the effects of ion-channel and ion-ion interactions involved in diffusive ionic motion through biological channels. The model under consideration involves (i) the joint diffusive motion of an ion and a constrained dipole (or charged oscillator) part of the channel wall with Coulombic interactions, (ii) the mean field, inter-ionic interactions at the entrance and exit to the channel and the mean field interactions of the ion with the permanent charge inside the pore, and (iii) the motion of an ion in the pore with interaction with the mean field and with a constrained dipole (or charged oscillator) part of the channel. The theoretical work will concentrate on modeling, analyzing, and simulating the random motion described in these conditions. This award is supported by several programs at NSF: Applied Mathematics, Cell Biology, Biophysics, Computational Neuroscience, and Computational Biology.

9405440 Eisenberg该奖项的主题是通过生物通道扩散离子运动中涉及的离子通道和离子-离子相互作用的影响的理论研究。 所考虑的模型包括（i）离子和受约束偶极子的联合扩散运动（ii）平均场、通道入口和出口处的离子间相互作用以及离子与孔内永久电荷的平均场相互作用，以及（iii）离子在孔中的运动，其与平均场以及与通道的受约束偶极（或带电振荡器）部分相互作用。 理论工作将集中在建模，分析和模拟这些条件下描述的随机运动。 该奖项由NSF的几个项目支持：应用数学，细胞生物学，生物物理学，计算神经科学和计算生物学。