Sperm ciliary gating and midpiece formation – a novel player and process
Sperm ciliary gating and midpiece formation – a novel player and process
批准号:
DP230100747
负责人:
Prof Moira O'Bryan
金额:
$43.44万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-01-01 至 2025-12-31
中文摘要
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英文摘要
We have identified CCDC112 an essential player in mammalian sperm tail development and male fertility. This project aims to define the role of CCDC112 in 1) the formation of the core to the sperm tail, the axoneme, and 2) the packaging of mitochondria into the midpiece. Within this Discovery Project we will define the mechanism(s) of CCDC112 functions and the consequences of its dysfunction. Insights from this grant will be of significance to fertility across mammals and may ultimately benefit the selection of highly fertile males within the agricultural sector.
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会议论文
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批准号:DP240100815
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负责人:Prof Moira O'Bryan
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财政年份:2020
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负责人:Prof Moira O'Bryan
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依托单位:
Finding the missing katanin required for male fertility
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批准号:nhmrc : 1138014
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项目类别:Project Grants
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财政年份:2018
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负责人:Prof Moira O'Bryan
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依托单位:
Mechanisms of manchette function
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批准号:DP180100533
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项目类别:Discovery Projects
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资助金额:$24.37万
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财政年份:2018
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负责人:Prof Moira O'Bryan
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依托单位:
Finding the missing katanin required for male fertility
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批准号:nhmrc : GNT1138014
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项目类别:Project Grants
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资助金额:$41.72万
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财政年份:2018
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负责人:Prof Moira O'Bryan
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依托单位:
The genetic causes of male infertility
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批准号:nhmrc : 1120356
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项目类别:Project Grants
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资助金额:$106.14万
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财政年份:2017
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负责人:Prof Moira O'Bryan
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依托单位:
A novel microtubule severing protein involved in male germ cell biology
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批准号:DP160100647
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项目类别:Discovery Projects
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资助金额:$27.84万
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财政年份:2016
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负责人:Prof Moira O'Bryan
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依托单位:
Male fertility and health
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批准号:nhmrc : GNT1058356
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Moira O'Bryan
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依托单位:
Male germ cell development - fertility and health
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批准号:nhmrc : 1058356
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Moira O'Bryan
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依托单位:
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility
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批准号:DP120101703
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项目类别:Discovery Projects
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资助金额:$24.65万
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财政年份:2012
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负责人:Prof Moira O'Bryan
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依托单位:
A novel DNA damage repair protein as a regulator of DNA double strand break repair and genome integrity
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批准号:DP110102288
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项目类别:Discovery Projects
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资助金额:$25.33万
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财政年份:2011
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负责人:Prof Moira O'Bryan
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 545805
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项目类别:NHMRC Research Fellowships
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资助金额:$42.79万
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财政年份:2009
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负责人:Prof Moira O'Bryan
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依托单位:
The identification of male meiosis genes using a new mouse line and human genome scans for gene copy number variations
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批准号:nhmrc : 490916
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项目类别:NHMRC Project Grants
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资助金额:$40.33万
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财政年份:2008
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负责人:Prof Moira O'Bryan
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依托单位:
Research Fellowship - Grant ID:384132
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批准号:nhmrc : 384132
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项目类别:NHMRC Research Fellowships
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资助金额:$21.52万
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财政年份:2006
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负责人:Prof Moira O'Bryan
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依托单位:
The Biology of Sperm Tail Development
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批准号:nhmrc : 143781
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项目类别:Career Development Fellowships
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资助金额:$20.87万
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财政年份:2001
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负责人:Prof Moira O'Bryan
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依托单位:
The expression and regulation of nitric oxide synthases in the male reproductive tract
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批准号:nhmrc : 967135
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项目类别:Early Career Fellowships
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资助金额:$14.75万
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财政年份:1996
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负责人:Prof Moira O'Bryan
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依托单位:
海外基金