Sperm ciliary gating and midpiece formation – a novel player and process

精子纤毛门控和中段形成——新颖的参与者和过程

• 批准号: DP230100747
• 负责人: Prof Moira O'Bryan
• 金额: $ 43.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100747
• 关键词: Sperm; ciliary; gating; midpiece; formation

We have identified CCDC112 an essential player in mammalian sperm tail development and male fertility. This project aims to define the role of CCDC112 in 1) the formation of the core to the sperm tail, the axoneme, and 2) the packaging of mitochondria into the midpiece. Within this Discovery Project we will define the mechanism(s) of CCDC112 functions and the consequences of its dysfunction. Insights from this grant will be of significance to fertility across mammals and may ultimately benefit the selection of highly fertile males within the agricultural sector.

我们已经确定了CCDC112在哺乳动物精子尾部发育和雄性生育力中的重要作用。该项目旨在确定CCDC112在1）精子尾部核心，轴丝的形成和2）线粒体包装到中段中的作用。在这个发现项目中，我们将定义CCDC112功能的机制及其功能障碍的后果。这项研究对哺乳动物的生育能力具有重要意义，并可能最终有利于农业部门对高生育力雄性的选择。