Sperm ciliary gating and midpiece formation – a novel player and process
Sperm ciliary gating and midpiece formation – a novel player and process
批准号:
DP230100747
负责人:
Prof Moira O'Bryan
金额:
$43.44万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-01-01 至 2025-12-31
中文摘要
我们已经发现CCDC112在哺乳动物精子尾部发育和雄性生育中起着重要作用。该项目旨在确定CCDC112在1)核心到精子尾巴、轴丝的形成以及2)线粒体包装到中段中所起的作用。在这个发现项目中,我们将定义CCDC112的功能机制(S)及其功能障碍的后果。来自这笔赠款的见解将对哺乳动物的生育能力具有重要意义,并最终可能有利于在农业部门选择高生育能力的雄性动物。
英文摘要
We have identified CCDC112 an essential player in mammalian sperm tail development and male fertility. This project aims to define the role of CCDC112 in 1) the formation of the core to the sperm tail, the axoneme, and 2) the packaging of mitochondria into the midpiece. Within this Discovery Project we will define the mechanism(s) of CCDC112 functions and the consequences of its dysfunction. Insights from this grant will be of significance to fertility across mammals and may ultimately benefit the selection of highly fertile males within the agricultural sector.
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会议论文
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财政年份:2018
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Finding the missing katanin required for male fertility
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财政年份:2018
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依托单位:
The genetic causes of male infertility
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批准号:nhmrc : 1120356
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依托单位:
A novel microtubule severing protein involved in male germ cell biology
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财政年份:2016
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负责人:Prof Moira O'Bryan
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依托单位:
Male fertility and health
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批准号:nhmrc : GNT1058356
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Moira O'Bryan
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依托单位:
Male germ cell development - fertility and health
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批准号:nhmrc : 1058356
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Moira O'Bryan
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依托单位:
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility
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批准号:DP120101703
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项目类别:Discovery Projects
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资助金额:$24.65万
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财政年份:2012
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负责人:Prof Moira O'Bryan
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依托单位:
A novel DNA damage repair protein as a regulator of DNA double strand break repair and genome integrity
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批准号:DP110102288
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项目类别:Discovery Projects
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资助金额:$25.33万
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财政年份:2011
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负责人:Prof Moira O'Bryan
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 545805
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项目类别:NHMRC Research Fellowships
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资助金额:$42.79万
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财政年份:2009
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负责人:Prof Moira O'Bryan
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依托单位:
The identification of male meiosis genes using a new mouse line and human genome scans for gene copy number variations
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批准号:nhmrc : 490916
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项目类别:NHMRC Project Grants
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资助金额:$40.33万
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财政年份:2008
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负责人:Prof Moira O'Bryan
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依托单位:
Research Fellowship - Grant ID:384132
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批准号:nhmrc : 384132
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资助金额:$21.52万
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依托单位:
The Biology of Sperm Tail Development
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财政年份:2001
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依托单位:
The expression and regulation of nitric oxide synthases in the male reproductive tract
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项目类别:Early Career Fellowships
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依托单位:
海外基金