Maximizing male fertility: the role of CRISP proteins.

最大化男性生育能力：CRISP 蛋白的作用。

• 批准号: DP200100659
• 负责人: Prof Moira O'Bryan
• 金额: $ 45.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100659
• 关键词: Maximizing; male; fertility; role; CRISP

This project aims to investigate the function of cysteine rich secretory protein (CRISP) family members in fertility. It is expected to generate new knowledge on the role CRISP1 and 4 play in sperm competition in vivo, and thus, evolutionary processes; to define the role seminal plasma CRISPs play in fertility; and identify the mechanism underpinning their biological activities. This will be achieved using a range of innovative, state-of-the-art approaches. Expected outcomes and benefits include an enhanced knowledge of the mechanisms underpinning fertility and infertility, enhanced collaboration and research knowhow, and an evidence base for future applied projects aimed enhancing fertility in agricultural species.

本项目旨在研究富含半胱氨酸的分泌蛋白（CRISP）家族成员在生育中的功能。它有望产生关于CRISP 1和4在体内精子竞争中的作用以及进化过程的新知识;定义精浆CRISPs在生育中的作用;并确定其生物活性的机制。这将通过一系列创新的、最先进的方法来实现。预期的成果和效益包括提高对生育力和不育的机制的认识，加强合作和研究知识，以及为未来旨在提高农业物种生育力的应用项目提供证据基础。