Finding the missing katanin required for male fertility

寻找男性生育所需缺失的剑宁

• 批准号: nhmrc : GNT1138014
• 负责人: Prof Moira O'Bryan
• 金额: $ 41.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/finding-missing-katanin-male-fertility/1348109
• 关键词: Finding; missing; katanin; required; male

Microtubules are a key element of all cells, including in the male germ line. In this project we will define the function of the microtubule severing protein KATNA1 in male fertility. This will be achieved using a unique model and state-of-the-art technologies. This project will have immediate relevance to the 1 in 20 Australian men who suffer from infertility but will also inform KATNA1 function in the many other tissues where KATNA1 is produced.

微管是所有细胞的关键组成部分，包括男性生殖系。在这个项目中，我们将确定微管切断蛋白KATNA1在男性生育能力中的功能。这将使用独特的模型和最先进的技术来实现。这个项目将与1 / 20的澳大利亚男性不育症患者直接相关，但也将了解KATNA1在产生KATNA1的许多其他组织中的功能。