A novel microtubule severing protein involved in male germ cell biology

一种参与男性生殖细胞生物学的新型微管切断蛋白

• 批准号: DP160100647
• 负责人: Prof Moira O'Bryan
• 金额: $ 27.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-14 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100647
• 关键词: novel; microtubule; severing; protein; involved

The project aims to better understand the cellular and biochemical mechanisms underlying a key component of male fertility. Microtubules are a fundamental component of all cells. A mechanism that is increasingly recognised as essential for microtubules regulation is severing. It has been discovered that an uncharacterised microtubule severing protein, KATNAL2, has a key role in male germ cell development. This project aims to define the mechanisms underlying KATNAL2 function in the male germ line. It is expected that these data will generate a comprehensive picture of KATNAL2 function and provide foundation data of relevance across multiple species and tissues. In the longer term, it may also reveal a rational strategy for fertility enhancement or suppression.

该项目旨在更好地了解男性生育力关键组成部分的细胞和生化机制。微管是所有细胞的基本组成部分。越来越多的人认识到一种对微管调节至关重要的机制是切断。已经发现一种未表征的微管切割蛋白KATNAL2在雄性生殖细胞发育中具有关键作用。该项目旨在确定KATNAL2在男性生殖系中功能的机制。预计这些数据将全面了解KATNAL 2功能，并提供跨多个物种和组织的相关基础数据。从长远来看，它还可能揭示一种提高或抑制生育率的合理策略。