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A novel microtubule severing protein involved in male germ cell biology

A novel microtubule severing protein involved in male germ cell biology
一种参与男性生殖细胞生物学的新型微管切断蛋白
批准号:
DP160100647
负责人:
Prof Moira O'Bryan
金额:
$27.84万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-14 至 2018-12-31

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中文摘要
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英文摘要
The project aims to better understand the cellular and biochemical mechanisms underlying a key component of male fertility. Microtubules are a fundamental component of all cells. A mechanism that is increasingly recognised as essential for microtubules regulation is severing. It has been discovered that an uncharacterised microtubule severing protein, KATNAL2, has a key role in male germ cell development. This project aims to define the mechanisms underlying KATNAL2 function in the male germ line. It is expected that these data will generate a comprehensive picture of KATNAL2 function and provide foundation data of relevance across multiple species and tissues. In the longer term, it may also reveal a rational strategy for fertility enhancement or suppression.
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