The identification of male meiosis genes using a new mouse line and human genome scans for gene copy number variations
The identification of male meiosis genes using a new mouse line and human genome scans for gene copy number variations
批准号:
nhmrc : 490916
负责人:
Prof Moira O'Bryan
金额:
$40.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
Infertility affects 1 in 25 Australian men and meiosis is a key process in male fertility, yet we know very little about the mechanisms that control it. We will use a new point mutant mouse model of meisois failure to identify a novel regulator of male fertility. Further, we hypothesize that changes in gene copy number will lead to meiosis arrest and infertility in some men. Such variations will be assessed through a whole genome scan of a unique set of infertile men.
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