The identification of male meiosis genes using a new mouse line and human genome scans for gene copy number variations

使用新的小鼠品系鉴定雄性减数分裂基因和人类基因组扫描基因拷贝数变异

• 批准号: nhmrc : 490916
• 负责人: Prof Moira O'Bryan
• 金额: $ 40.33万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-male-meiosis-number-variations/96800
• 关键词: identification; male; meiosis; genes; using

Infertility affects 1 in 25 Australian men and meiosis is a key process in male fertility, yet we know very little about the mechanisms that control it. We will use a new point mutant mouse model of meisois failure to identify a novel regulator of male fertility. Further, we hypothesize that changes in gene copy number will lead to meiosis arrest and infertility in some men. Such variations will be assessed through a whole genome scan of a unique set of infertile men.

不育症影响1在25澳大利亚男性和减数分裂是一个关键的过程在男性生育力，但我们知道很少的机制，控制it.We将使用一个新的点突变小鼠模型meisois失败，以确定一种新的调节男性生育力。此外，我们假设基因拷贝数的变化将导致减数分裂停滞和不育的一些男人。这些变异将通过对一组独特的不育男性进行全基因组扫描来评估。