Mathematical Sciences: Mathematical Models of Neural Processing in the Auditory Brainstem

数学科学：听觉脑干神经处理的数学模型

• 批准号: 9203352
• 负责人: Michael Reed
• 金额: $ 16.75万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-15 至 1996-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9203352&HistoricalAwards=false
• 关键词: Mathematical; Sciences; Models; Neural; Processing

The investigators will use mathematical analysis and computation to investigate neural processing in the auditory brainstem and midbrain. The project has four main topics: (1) Mathematical development of a model for azimuthal localization in the lateral superior olive based on intensity differences; (2) Development and analysis of computational models for azimuthal localization by the medial superior olive and avian analogues based on phase differences; (3) Models for the neural processing of echoes in the lateral lemniscus of the bat and mathematical questions of signal reconstruction; (4) General principles of neural processing. The purpose of this project is to understand the basic organizational principles of parts of the brain that analyze sounds. These parts are made up of small signaling devices called neurons, which are organized and connected so that they perform specific functions (for example, to determine the location of a sound based on the fact that the sound will be louder at the ear more closely directed toward the sound source). Progress in understanding these principles of organization may make possible the design of artificial hearing devices that could be used in industrial robots or could be used to improve the hearing of humans with serious hearing deficiencies.

研究人员将使用数学分析和计算来研究听觉脑干和中脑的神经处理过程。该项目有四个主要主题：(1)基于强度差异的侧上橄榄方位定位模型的数学发展；(2)基于相位差的橄榄和鸟类内侧上缘类似物方位定位计算模型的开发与分析；(3)蝙蝠外侧小网膜回声的神经处理模型及信号重建的数学问题；(4)神经处理的一般原理。这个项目的目的是了解大脑中分析声音部分的基本组织原理。这些部分由被称为神经元的小信号装置组成，它们被组织和连接起来，以便执行特定的功能（例如，根据声音在靠近声源的耳朵处声音会更大这一事实来确定声音的位置）。在理解这些组织原理方面的进展可能使人工听力设备的设计成为可能，这些设备可以用于工业机器人或用于改善严重听力缺陷的人类的听力。